Potential aluminum exposure from parenteral nutrition in patients with acute kidney injury

The Annals of Pharmacotherapy
Rex O BrownRoland N Dickerson

Abstract

Patients' exposure to and potential toxicity from aluminum in parenteral nutrition (PN) formulations is an important concern of healthcare providers. To determine the potential for aluminum toxicity caused by PN in hospitalized adults who have risk factors of both acute kidney injury and PN. Adults who required PN and had a serum creatinine (SCr) level at least 1.5 times greater than the admission SCr on the first day of PN were studied in a retrospective fashion. Protein was administered based on whether hemodialysis was being used (0.6-1 g/kg/day without hemodialysis; 1.2-1.5 g/kg/day with hemodialysis). Aluminum exposure was determined for each patient by multiplying the volume of each PN component by its concentration of aluminum. Unpaired t-tests, Fisher's exact test, and analysis of variance were used for statistical analysis. Data are presented as mean +/- SD. Thirty-six patients (aged 50.4 +/- 20.4 y; weight 90.2 +/- 32.8 kg) were studied. Initial serum urea nitrogen and SCr were 47 +/- 23 and 3.3 +/- 1.4 mg/dL, respectively. Twelve patients received hemodialysis. The mean aluminum exposure was 3.8 +/- 2 microg/kg/day in the 36 patients. Of these, 29 had safe calculated aluminum exposure (<5 microg/kg/day) and 7 had hig...Continue Reading

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Citations

Feb 14, 2013·European Journal of Clinical Nutrition·A Hernández-SánchezM Arteta-Jiménez
Apr 26, 2016·Journal of Pediatric Gastroenterology and Nutrition·Robert A Yokel, Jason M Unrine
Jul 22, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jane M GervasioMichael Holowatyj
Aug 27, 2015·European Journal of Mass Spectrometry·Nagasathiya KrishnanVairamani Mariappanadar
Mar 20, 2015·Environmental Science and Pollution Research International·Hewa M S WasanaJayasundera Bandara
Feb 6, 2020·Indian Journal of Nephrology·Urmila AnandhVikas Aggarwal

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