Potential and limitations of intervertebral disc endogenous repair

Current Stem Cell Research & Therapy
Zhen LiSibylle Grad

Abstract

Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential of endogenous repair in the IVD, the recent findings on endogenous IVD progenitor cells, and stem cell niches involved in IVD endogenous repair. We also highlight the factors which may restrict IVD self-healing. Ultimately, advanced therapeutic attempts to boost endogenous repair in the IVD are discussed, including bioactive factor delivery, gene therapy, activation of endogenous IVD progenitor cells and chemokine mediated stem cell homing.

Citations

Apr 28, 2016·Oxidative Medicine and Cellular Longevity·Olga KrupkovaKarin Wuertz-Kozak
Oct 24, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daniela A FrauchigerBenjamin Gantenbein
Feb 5, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Feng WangXiao-Tao Wu
Jun 27, 2020·Frontiers in Bioengineering and Biotechnology·Zhen LiGernot Lang
Mar 16, 2017·Stem Cells Translational Medicine·Carla CunhaMário A Barbosa
Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·Yanbin ZhangLiming Xiong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

The Journal of the American Academy of Orthopaedic Surgeons
Sibylle GradMauro Alini
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Fei WangDa-di Jin
Expert Opinion on Biological Therapy
Helen E Gruber, Edward N Hanley
© 2022 Meta ULC. All rights reserved