Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans.

Journal of Natural Medicines
Daisuke MukaiToru Yamasaki

Abstract

A novel gallate of tannin, (-)-epigallocatechin-(2 beta-->O-->7',4 beta-->8')-epicatechin-3'-O-gallate (8), together with (-)-epicatechin-3-O-gallate (4), (-)-epigallocatechin (5), (-)-epigallocatechin-3-O-gallate (6), and (+)-gallocatechin-(4 alpha-->8')-epigallocatechin (7), were isolated from the tea plant Camellia sinensis (L.) O. Kuntze var. sinensis (cv., Yabukita). The structure of 8, including stereochemistry, was elucidated by spectroscopic methods and hydrolysis. The compounds, along with commercially available pyrogallol (1), (+)-catechin (2), and (-)-epicatechin (3), were examined for toxicity towards egg-bearing adults of Caenorhabditis elegans. The anthelmintic mebendazole (9) was used as a positive control. Neither 2 nor 3 were toxic but the other compounds were toxic in the descending order 8, 7 approximately 6, 9, 4, 5, 1. The LC(50) (96 h) values of 8 and 9 were evaluated as 49 and 334 micromol L(-1), respectively. These data show that many green tea polyphenols may be potential anthelmintics.

References

Aug 24, 1999·Veterinary Parasitology·T G GearyD P Thompson
Feb 24, 2001·Phytochemistry·A L BarreirosJ M David
Sep 6, 2003·Trends in Parasitology·John Horton

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Citations

Jun 9, 2009·Mechanisms of Ageing and Development·Nadine SaulChristian E W Steinberg
Dec 3, 2014·Ecotoxicology and Environmental Safety·ZhenYang YuHuiPing Deng
May 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jacqueline Dikti VildinaDieudonne Ndjonka
Mar 23, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hong-Fang JiangWei-Ming Zhang

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.