Potential Anti-Aging Substances Derived from Seaweeds.

Marine Drugs
Lei CaoHyeung-Rak Kim

Abstract

Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathways, such as sirtuin, AMP-activated protein kinase, insulin-like growth factor, autophagy, and nuclear factor erythroid 2-related factor 2 play critical roles in regulating aging. Furthermore, genetic or dietary interventions of these pathways can extend lifespan by delaying the aging process. Seaweeds are a food source rich in many nutrients, including fibers, polyunsaturated fatty acids, vitamins, minerals, and other bioactive compounds. The health benefits of seaweeds include, but are not limited to, antioxidant, anti-inflammatory, and anti-obese activities. Interestingly, a body of studies shows that some seaweed-derived extracts or isolated compounds, can modulate these aging-regulating pathways or even extend lifespans of various animal models. However, few such studies have been conducted on higher animals or even humans. In this review, we focused on potential anti-aging bioactive substances in seaweeds that have been studied in cells and animals mainly based on their anti-ag...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Jul 13, 2002·Trends in Biochemical Sciences·Thomas von Zglinicki
Aug 15, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Andrea M Vincent, Eva L Feldman
Jan 25, 2003·Science·Matthias BlüherC Ronald Kahn
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Jan 14, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tapiwanashe MagwereLinda Partridge
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Blanka Rogina, Stephen L Helfand
Mar 18, 2005·Aging Cell·Diana van HeemstRudi G J Westendorp
Aug 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsuzakiAkiyoshi Fukamizu
Aug 5, 2005·Molecular Biology of the Cell·Eriko MichishitaIzumi Horikawa
Jan 28, 2006·Cell·Raul MostoslavskyFrederick W Alt
Feb 8, 2006·Current Biology : CB·Dario R ValenzanoAlessandro Cellerino
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
Sep 20, 2007·Aging Cell·Laura BordoneLeonard Guarente
Oct 12, 2007·Biochimie·Sophie PattingrePatrice Codogno
Jan 16, 2008·Developmental Cell·Gerasimos P Sykiotis, Dirk Bohmann
Jan 29, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tingting ZhaoZhien Li
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bradley J WillcoxJ David Curb
Sep 23, 2008·Cell Death and Differentiation·M C MaiuriG Kroemer
Apr 3, 2009·Journal of Agricultural and Food Chemistry·A-Reum KimHyeung-Rak Kim
Apr 28, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chang-Suk KongSe-Kwon Kim
May 7, 2009·Rejuvenation Research·Chiara Viviani AnselmiAnnibale Alessandro Puca
Jun 6, 2009·Aging Cell·Ludmila PawlikowskaUNKNOWN Study of Osteoporotic Fractures
Jun 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Soo-Jin HeoYou-Jin Jeon
Jul 10, 2009·Nature·David E HarrisonRichard A Miller
Sep 1, 2009·Nature Medicine·Tohru MinaminoIssei Komuro
Sep 8, 2009·Nature Medicine·Rexford S Ahima
Nov 17, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Changkeun KangEuikyung Kim
Jan 28, 2010·American Journal of Physiology. Endocrinology and Metabolism·Neil B RudermanYasuo Ido
Apr 1, 2010·Journal of Nutritional Science and Vitaminology·Hyeon Ju LeeChung Mo Nam
Apr 7, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tae Hoon Kim, Jong-Sup Bae
Jul 6, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seung-Hong LeeYou-Jin Jeon
Jan 1, 2009·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Suzana MakpolWan Zurinah Wan Ngah
Sep 28, 2010·Ageing Research Reviews·Elad Ziv, Donglei Hu
Nov 26, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Gerasimos P SykiotisDirk Bohmann

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
nuclear translocation

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.