Abstract
Anti-inflammatory assay-guided separation of extracts from the roots of Caesalpinia mimosoides Lamk. led to isolation of seven compounds: four diterpenes (1-4), a dimer (9), and two dibenzo[b,d]furans (10, 11) together with eleven known compounds. Their structures were elucidated by 1D- and 2D-NMR techniques as well as UV, IR, mass spectral data and comparison with literature values. The anti-inflammatory activities of all compounds were evaluated for inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cell lines. Compounds 4, 6, 8, and 12-14 were also tested for the inhibitory effect on LPS-induced tumor necrosis factor-alpha (TNF-alpha) release in RAW264.7 cells. The results indicated that 4 possessed potent inhibitory activity for both tests with IC(50) values of 3.0 and 6.5 microM, respectively.
Citations
Nov 2, 2013·Phytochemistry·Mario A Gómez-HurtadoRosa E del Río
Oct 18, 2011·Journal of Natural Products·Xiao-Ning WangA A Leslie Gunatilaka
Dec 7, 2013·Journal of Natural Products·Yong ZhengLi-Jiang Xuan
Jun 6, 2012·Advances in Pharmacological Sciences·J A ShilpiS D Sarker
May 4, 2011·Malaria Journal·Ana Carolina A V KayanoFabio T M Costa
Jan 18, 2015·Fitoterapia·Gan B Bajracharya
Oct 5, 2011·Fitoterapia·Charles O Ochieng'Ismail O Ishola
Oct 21, 2015·Phytochemistry·Sayuri KamikawaShinji Ohta
Jul 1, 2015·Phytochemistry·Ruijuan DongHuiyuan Gao
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Adisak PalasapJureerut Daduang
Apr 9, 2013·Bioorganic & Medicinal Chemistry Letters·Charles O OchiengHosea Akala
Jun 28, 2016·Fitoterapia·Weihua MuLiqin Wang
Oct 9, 2016·Journal of Ethnopharmacology·Pradeep Bhaskar BhatGangadhar S Mulgund
Nov 14, 2016·International Immunopharmacology·Partha PalitBiswanath Bhunia
Jul 4, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João L Baldim ZaninMarisi G Soares
Jun 30, 2011·Natural Product Reports·James R Hanson
Mar 18, 2020·Chemistry & Biodiversity·De-Sheng WangQinshi Zhao
Jul 10, 2019·BMC Complementary and Alternative Medicine·Panthakarn RangsinthTewin Tencomnao
Aug 16, 2017·Natural Product Research·Dewen BiLiqin Wang
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Narintorn RattanataJureerut Daduang
May 31, 2019·Biomedical Chromatography : BMC·Miao WangZhaohua Wu
Jun 30, 2021·Chemistry & Biodiversity·Jun CaoLigen Lin
Aug 3, 2021·Journal of Natural Products·Miao WangHuiyuan Gao
Apr 10, 2012·Journal of Chemical Theory and Computation·Matthew R SiebertWilliam L Hase
Oct 30, 2018·Organic Letters·Houda ZentarEnrique Alvarez-Manzaneda
Feb 26, 2019·Journal of Chemical Information and Modeling·Ying WangHuiyuan Gao
Jul 1, 2020·Journal of Natural Products·Achara RaksatKhanitha Pudhom
Nov 19, 2021·Journal of Asian Natural Products Research·Lian LianMiao Wang