Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd

International Journal of Molecular Medicine
Nuramina MamatHaji Akber Aisa

Abstract

Vitiligo is a depigmentation disorder of the skin. It is primarily caused by the destruction of melanocytes or obstruction of the melanin synthesis pathway. Melanin is a type of skin pigment that determines skin color. The seeds of Vernonia anthelmintica (L.) Willd (Kaliziri) are used for treating skin diseases including vitiligo in traditional Uyghur medicine. 1,5‑Dicaffeoylquinic acid (1,5‑diCQA) is a natural polyphenolic compound widely distributed in plants and extracted from Kaliziri seeds. Therefore, in the present study, the effect of 1,5‑diCQA on melanin synthesis in B16 cell was evaluated, and its molecular mechanism was explored. The results indicated that 1,5‑diCQA treatment of B16 cells stimulated an increase of intracellular melanin level and tyrosinase (TYR) activity without cytotoxicity. Reverse transcription quantitative polymerase chain reaction results also indicated that 1,5‑diCQA may markedly improve the protein expression and RNA transcription of microphthalmia‑associated transcription factor (MITF), melanogenic enzyme Tyr, tyrosinase‑related protein 1 (TRP 1) and tyrosinase‑related protein 2 (TRP 2). Additional results identified that 1,5‑diCQA may promote the phosphorylation of p38 mitogen‑activated prote...Continue Reading

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Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·SeoYeon ShinKyungMok Park
May 1, 2021·International Journal of Molecular Sciences·Yifan LaiHui Zhong
May 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Abudujilili AbuduainiHaji Akbar Aisa

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Methods Mentioned

BETA
protein assay
PCR
ELISA

Software Mentioned

SPSS
Quantity One
Graphpad Prism

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