Potential anticancer activity and mechanism of action of nanoformulated curcumin in experimental Ehrlich ascites carcinoma-bearing animals

Nanomedicine
Mohamed El-FarIbrahim M El-Sherbiny

Abstract

To study the potential use of nanoformulations of curcumin (CUR); CUR-loaded pluronic nanomicelles (CURnp1), and CUR-loaded poly(lactic-co-glycolic acid) nanoparticles (CURnp2) as antitumor agents in Ehrlich ascites carcinoma-bearing animals, and their mechanism of action. CURnp1 and CURnp2 were prepared, characterized and tested against Ehrlich ascites carcinoma-bearing mice. Superoxide dismutase, catalase (CAT), glutathione, malondialdehyde, histopathological, immunohistochemical studies, cell cycle and caspase-3 were investigated. CURnp1 destroyed tumors via increasing superoxide dismutase, CAT and glutathione, decreasing malondialdehyde through inducing apoptosis by decreasing Ki-67 and Bcl2 expression and activating caspase-3 leading to inhibition of proliferation and cell cycle arrest with progression at G1/S phase. The study demonstrated for the first time superiority of CURnp1 over native CUR and CURnp2 as anticancer agents.

References

Feb 1, 1991·Planta medica·H P Ammon, M A Wahl
Nov 1, 1987·Chemistry and Physics of Lipids·K Yagi
Jul 4, 1998·British Journal of Cancer·L S CooperD M Barnes
Mar 5, 1999·Mutation Research·L J Marnett
May 19, 2000·Breast Cancer Research and Treatment·W H GoodsonF M Waldman
Sep 22, 2000·Trends in Biotechnology·S M Moghimi, A C Hunter
Oct 26, 2001·Biochemical and Biophysical Research Communications·S PalG Sa
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
Sep 3, 2002·Advanced Drug Delivery Reviews·Alexander V KabanovValery Yu Alakhov
Feb 24, 2004·Journal of Pharmacological Sciences·Malaya GuptaMadgula Lakshmi Mohan Vamsi
Jan 14, 2005·Molecular and Cellular Biochemistry·Marian ValkoJoshua Telser
Jul 12, 2005·Veterinary Pathology·J A Ramos-Vara
Mar 21, 2006·Apoptosis : an International Journal on Programmed Cell Death·J ChenP X Chen
Jul 27, 2007·Drug Development and Industrial Pharmacy·Vjera Grabovac, Andreas Bernkop-Schnürch
Jun 7, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V Batrakova, Alexander V Kabanov
Jul 16, 2008·Pharmaceutical Research·Preetha AnandBharat B Aggarwal
Sep 5, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rachel C VreemanWinstone M Nyandiko
Sep 16, 2008·Molecular Nutrition & Food Research·Vittorio CalabreseAlbena T Dinkova-Kostova
May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Fei YanLaiqiang Huang
Nov 6, 2009·Journal of Physiology and Biochemistry·A ValdiviaJ Jordán
Feb 16, 2010·The Lancet Oncology·Rinat YerushalmiKaren A Gelmon
Mar 11, 2010·Current Medicinal Chemistry·G Bar-SelaM Schaffer
May 25, 2010·Drug Delivery·Ali SeyfoddinRaida Al-Kassas
May 26, 2010·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·V RaffaA Cuschieri
Sep 15, 2010·Free Radical Research·Agnieszka AugustyniakNeven Zarković
Nov 30, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Vandita KakkarIndu Pal Kaur
May 10, 2011·Journal of Ethnopharmacology·Mariana Flavia da MotaMarize Campos Valadares
Jun 7, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Purusotam Basnet, Natasa Skalko-Basnet
Jun 29, 2011·Drug Development and Industrial Pharmacy·Mohamed El-FarIbrahim M El-Sherbiny
Jul 7, 2011·International Journal of Pharmaceutics·Yin-Meng TsaiTung-Hu Tsai
Jul 30, 2011·Journal of Agricultural and Food Chemistry·Xiaoxia XieShuqin Yu
Sep 7, 2011·Current Drug Metabolism·Murali Mohan YallapuSubhash Chand Chauhan
Sep 27, 2012·Colloids and Surfaces. B, Biointerfaces·Najeh Maissar KhalilRubiana Mara Mainardes
Mar 27, 2013·Pharmaceutical Biology·Indrajit KarmakarPallab Kanti Haldar
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Wei ZhangJun-Li Liu

❮ Previous
Next ❯

Citations

Jul 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed R GardouhMona K E Qushawy

❮ Previous
Next ❯

Methods Mentioned

BETA
nanoprecipitation
dynamic light scattering
flow cytometry
MDA

Software Mentioned

SPSS
Cellquest
CURnp
GraphPad Prism
FACSCalibur
Statistical package for social science
NanoScope Analysis

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis