Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts of Ricinus communis leaves on streptozotocin-induced diabetes in rats

PeerJ
Mohamed A M Gad-ElkareemAdel Kadri

Abstract

Recently, herbal drugs and their bioactive compounds have gained popularity in the management of diabetes mellitus (DM), which has become an epidemic disease all over the world and is especially prevalent in the Kingdom of Saudi Arabia (KSA). This study aimed to investigate the antidiabetic effect of ethanolic and aqueous-ethanolic extracts of wild Ricinus communis (R. communis) leaves in streptozotocin (STZ) induced diabetic rats. Diabetic rats were administered orally with the mentioned extracts at doses of 300 and 600 mg/kg/BW for 14 days, and the obtained results of different biochemical parameters were compared with normal control, diabetic control and standard drug glibenclamide (5 mg/kg/BW). The obtained results revealed a remarkable and significantly (P < 0.05) reverse effect of the body weight loss, observed when diabetic rats were treated with ethanol and aqueous-ethanol extracts at 300 mg/kg/BW. Administration of the ethanol extract at 600 mg/kg/BW significantly (P < 0.05) reduced the blood glucose level. A significant increase in the AST, ALT and ALP levels (P < 0.05) was observed in the diabetic control and in the experimental groups with glibenclamide which was also significantly (P < 0.05) lowered after treatment...Continue Reading

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Citations

Sep 7, 2019·Journal of Food Biochemistry·Rana EssaAhmed Abdellatif
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Basiru Olaitan AjiboyeBabatunji Emmanuel Oyinloye
Nov 17, 2019·Journal of Ethnopharmacology·Dele Moses Adams, Musa Toyin Yakubu
Mar 2, 2021·Metabolic Syndrome and Related Disorders·Juan Manuel Salgado-RománJoel Ramírez-Emiliano

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Methods Mentioned

BETA
deamination

Software Mentioned

SPSS

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