Potential application of nanochitosan film as a therapeutic agent against cutaneous leishmaniasis caused by L. major

Parasitology Research
Somayeh BahramiFatemeh Ahmadi

Abstract

Antileishmanial drugs traditionally used for treatment of cutaneous leishmaniasis are mainly toxic, ineffective for some parasite isolates, and costly. Since chitosan is reported to accelerate wound healing, the aims of this study were to assess the effectiveness of nanochitosan films in the treatment of cutaneous leishmaniasis caused by Leishmania major (Iranian strain) and to investigate alterations of antioxidant enzyme activities and malondialdehyde levels. Six weeks after L. major inoculation, when lesions appeared at the base of the tail of 36 female Balb/c mice, treatment was initiated. Lesion sizes, parasite proliferation, histopathological changes, antioxidant enzyme activities, and malondialdehyde changes were evaluated in groups treated with nanochitosan film and groups treated with the combination of nanochitosan film and daily peritoneal injection of glucantime. There was no significant difference between nanochitosan and glucantime in reduction of lesion size. But, lesion sizes in the group that was treated with a combination of nanochitosan film and glucantime were significantly reduced from 2 weeks after treatment. The results of the present study showed that application of nanochitosan film increased the wound ...Continue Reading

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Dec 25, 2019·Antimicrobial Agents and Chemotherapy·Alaa RiezkSimon L Croft
Sep 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Philippe M LoiseauSimon L Croft
Feb 26, 2020·Food and Waterborne Parasitology·Neda KonstantinovicFlorence Robert-Gangneux
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May 22, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Tony JinAudrey Moores

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