Abstract
Soy isoflavones (Ifs), which are natural phytoestrogens, have beneficial effects in cardiovascular disease. We have previously shown that genistein, the most active component of Ifs, inhibits pulmonary vascular structural remodeling and right ventricular hypertrophy induced by chronic hypoxia in male Wistar rats. This study aimed to evaluate the effects of Ifs on right ventricular and pulmonary hemodynamics in individuals with chronic mountain sickness (CMS). Twenty-eight male patients living on the Qinghai-Tibetan plateau (5,200 m) who were suffering from CMS were treated orally with Ifs (20 mg, twice daily) for 45 days. Physiological and plasma biochemical indices, hematology and echocardiography were investigated. It was observed that 45 days of treatment with Ifs significantly increased blood oxygen saturation and markedly decreased the CMS score and heart rate (all P<0.05) of the subjects. Following treatment with Ifs, hematocrit (P<0.05), hemoglobin concentration (P<0.01) and plasma levels of malondialdehyde (P<0.05) were significantly decreased, while plasma levels of nitric oxide (P<0.01) and the plasma activity of nitric oxide synthase (P<0.01) and superoxide dismutase (P<0.01) were markedly increased compared with the...Continue Reading
References
Oct 1, 1992·International Journal of Sports Medicine·C Monge-CF León-Velarde
Mar 7, 1996·The New England Journal of Medicine·U ScherrerP Bärtsch
Apr 1, 1997·Cardiovascular Drugs and Therapy·V PelouchJ Widimský
Sep 27, 2000·The Journal of Nutritional Biochemistry·J LigginsS A Bingham
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y AllemannM Maggiorini
Mar 7, 2002·Lancet·Raul PlataUNKNOWN Commission on Global Advancement of Nephrology (COMGAN), Research Subcommittee of the International Society of Nephrology
May 1, 1996·Wilderness & Environmental Medicine·M VargasL Rey
Dec 16, 2003·High Altitude Medicine & Biology·Steve WoodMarlowe Eldridge
Jul 20, 2004·Journal of Applied Physiology·Tianyi WuZhigang Wang
Jun 17, 2005·The Journal of Pharmacology and Experimental Therapeutics·Rocío VeraJuan Duarte
Jul 19, 2005·Journal of Applied Physiology·Brian D HoitCynthia M Beall
Aug 3, 2005·High Altitude Medicine & Biology·Fabiola León-VelardeGustavo Zubieta-Calleja
Dec 15, 2005·High Altitude Medicine & Biology·Anjana G VijNarinder K Satija
Mar 7, 2007·Circulation·Dante Penaloza, Javier Arias-Stella
Apr 5, 2008·American Journal of Respiratory and Critical Care Medicine·Jean-Paul RichaletFabiola León-Velarde
Jun 24, 2008·The Journal of Nutrition·Wendy L HallThomas A B Sanders
Mar 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Gustavo F GonzalesCynthia Gonzales-Castañeda
Jun 16, 2009·Fertility and Sterility·Jill M Hamilton-ReevesMark J Messina
Jan 14, 2010·Journal of Agricultural and Food Chemistry·Hyuck KimWon-Hwan Park
Sep 30, 2010·The Journal of Physiology·Damian M BaileyMarc M Berger
Oct 28, 2010·Experimental Hematology·Peng LiYu-qi Gao
Jan 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Ri-Li GeBenjamin D Levine
May 10, 2011·Endocrine·Gustavo F GonzalesCynthia Gonzales-Castañeda
Nov 11, 2011·Mini Reviews in Medicinal Chemistry·V B GencelR A Khalil
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·Cynthia M BeallMario Barragan