Potential biomarker panels in overall breast cancer management: advancements by multilevel diagnostics

Personalized Medicine
Shantanu GirotraOlga Golubnitschaja

Abstract

Breast cancer (BC) prevalence has reached an epidemic scale with half a million deaths annually. Current deficits in BC management include predictive and preventive approaches, optimized screening programs, individualized patient profiling, highly sensitive detection technologies for more precise diagnostics and therapy monitoring, individualized prediction and effective treatment of BC metastatic disease. To advance BC management, paradigm shift from delayed to predictive, preventive and personalized medical services is essential. Corresponding step forwards requires innovative multilevel diagnostics procuring specific panels of validated biomarkers. Here, we discuss current instrumental advancements including genomics, proteomics, epigenetics, miRNA, metabolomics, circulating tumor cells and cancer stem cells with a focus on biomarker discovery and multilevel diagnostic panels. A list of the recommended biomarker candidates is provided.

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Citations

Aug 20, 2016·Clinical & Experimental Metastasis·Olga Golubnitschaja, Krishna Chander Sridhar
May 21, 2019·Journal of Cellular Biochemistry·Fangfang XuChengjiu Hu
Nov 2, 2016·The EPMA Journal·Olga GolubnitschajaVincenzo Costigliola
Jul 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Olga GolubnitschajaGodfrey Grech

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Methods Mentioned

BETA
metabolomics profiling
NMR

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