PMID: 8943072Nov 26, 1996Paper

Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat

Proceedings of the National Academy of Sciences of the United States of America
J S LinM Jouvet

Abstract

Much experimental and clinical data suggest that the pharmacological profile of modafinil, a newly discovered waking substance, differs from those of amphetamine and methylphenidate, two classical psychostimulants. The brain targets on which modafinil acts to induce wakefulness, however, remain unknown. A double-blind study using the protooncogene c-fos as experimental marker in the cat was, therefore, carried out to identify the potential target neurons of modafinil and compare them with those for amphetamine and methylphenidate. Cats were sacrificed after a single oral administration of amphetamine, methylphenidate, or modafinil at equivalent doses for wake induction (1, 2.5, or 5 mg/kg, respectively) and brain sections examined for Fos by immunocytochemistry. Administration of either amphetamine or methylphenidate evoked Fos-like immunoreactivity in a large number of neurons in the striatum and whole cortex, especially in the caudate nucleus and mediofrontal cortex, which are known to be dopaminergic targets. In contrast, administration of modafinil resulted in the labeling of few cells in these structures, but did induce marked Fos labeling in neurons of the anterior hypothalamic nucleus and adjacent areas. These results pr...Continue Reading

References

Dec 15, 1978·The Journal of Comparative Neurology·C B SaperW M Cowan
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T F Freund, V Meskenaite
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S T YoungM J Iadarola
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson
Nov 1, 1989·Trends in Neurosciences·J I Morgan, T Curran
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·H Bastuji, M Jouvet
Apr 8, 1987·The Journal of Comparative Neurology·R E HarlanD W Pfaff
Apr 1, 1994·The European Journal of Neuroscience·J S LinM Jouvet
Jan 12, 1996·Science·J E SherinC B Saper
May 1, 1996·Neuron·S E Hyman
Jul 1, 1946·Journal of Neurophysiology·W J H NAUTA

❮ Previous
Next ❯

Citations

Mar 19, 2009·JAMA : the Journal of the American Medical Association·Nora D VolkowKaren Apelskog-Torres
Jul 12, 2002·Synapse·Servet M YatinBertha K Madras
Feb 15, 2011·Cellular and Molecular Life Sciences : CMLS·Jian-Sheng LinHelmut L Haas
Jul 29, 2011·Pflügers Archiv : European journal of physiology·Helmut L Haas, Jian-Sheng Lin
Mar 4, 2005·Current Neurology and Neuroscience Reports·Jay H Rosenberg, Renata Shafor
Jul 31, 2012·Current Psychiatry Reports·Josephine EliaKarin Borgmann-Winter
Mar 9, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giacomo Della MarcaPietro Tonali
May 27, 2005·Brain Research. Developmental Brain Research·T D ChaseM Wilkinson
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Daniel BéracochéaChristophe Pierard
May 17, 2005·Physical Medicine and Rehabilitation Clinics of North America·William S MacAllister, Lauren B Krupp
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Daniel BéracochéaChristophe Pierard
Apr 30, 2002·Brain Research. Developmental Brain Research·Marsha R PennerRichard E Brown
Jul 20, 2002·Drug and Alcohol Dependence·Craig R RushAdam F Wooten
Apr 12, 2003·Drug and Alcohol Dependence·Charles A DackisCharles P O'Brien
Oct 29, 2003·Pediatric Neurology·Thomas A Rugino, Teresa C Samsock
Jun 8, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·Kenneth R KaufmanAdriana Fitzsimmons
Oct 29, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yves DauvilliersJacques Montplaisir
Nov 11, 2003·Sleep Medicine·Anna IvanenkoDavid Gozal
Apr 1, 2009·Behavioral Neuroscience·Tristan ShumanStephan G Anagnostaras
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessandro GozziMarina Bentivoglio
Jan 8, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Motoyo Yano, Heinz Steiner
Aug 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J Minzenberg, Cameron S Carter
Sep 6, 2000·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C GuilleminaultD Leger
May 7, 2009·Journal of Palliative Medicine·Leslie BlackhallElena Farace
Dec 5, 2012·Journal of Palliative Medicine·Jennifer Cheng, Hunter Groninger
Sep 3, 2011·Zebrafish·Benjamín SigurgeirssonKarl Aegir Karlsson
Jul 20, 2007·Schizophrenia Bulletin·Sharon Morein-ZamirBarbara J Sahakian
Aug 31, 2007·Schizophrenia Bulletin·Ariel Y Deutch, Michael Bubser
Jul 6, 2000·The Journal of Head Trauma Rehabilitation·E Elovic
Apr 13, 2004·Neuroreport·Christianne M HawkenMichael Wilkinson
Oct 2, 2003·Clinical Neuropharmacology·Jonathan R L SchwartzRod J Hughes
Apr 20, 2004·Clinical Neuropharmacology·Murray H Rosenthal, Sharon L Bryant
Feb 24, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·T A Rugino, T C Copley
Oct 17, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·William N Pachas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.