Potential breakthroughs with investigational drugs for hairy cell leukemia

Expert Opinion on Investigational Drugs
Tadeusz RobakPawel Robak

Abstract

Hairy cell leukemia (HCL) is a rare subtype of B-cell chronic lymphoid leukemia. It is characterized by progressive pancytopenia, splenomegaly and infiltrations of the bone marrow, liver and spleen. Over the last few years, several new immunological drugs, particularly immunotoxins, BRAF inhibitors and B-cell receptor (BCR) pathway inhibitors have been developed and investigated as potential treatment options. This article summarizes recent investigational therapies of HCL, looking at their: mechanism of action, pharmacological properties, clinical activity and toxicity, as well as their emerging role in its treatment. The authors conducted a literature review of the MEDLINE database for articles in English concerning immunotoxins, BRAF inhibitors and BCR pathway inhibitors via PubMed. Publications from 2000 through to June 2015 were scrutinized. The search terms used were: BRAF, vemurafenib, dabrafenib, ibrutinib, monoclonal antibodies, immunotoxins, moxetumomab pasudotox, and rituximab in conjunction with HCL. The authors also searched manually the conference proceedings from the previous 5 years of the American Society of Hematology, European Hematology Association, American Society of Clinical Oncology, and ACR/ARHP Annual ...Continue Reading

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Citations

Mar 29, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Karen M Fancher, Zachary C Lally-Montgomery
May 3, 2019·Expert Opinion on Biological Therapy·Agnieszka Janus, Tadeusz Robak
Aug 10, 2017·Expert Opinion on Emerging Drugs·Anna Wolska-WasherTadeusz Robak
Aug 7, 2020·European Journal of Haematology·Pawel RobakTadeusz Robak
Nov 21, 2020·Annals of Hematology·Ewa RobakTadeusz Robak

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