Potential cancer chemopreventive agents from Arbutus unedo

Natural Product Research
Esperanza J Carcache-BlancoA Douglas Kinghorn

Abstract

A phytochemical study of the petroleum ether and ethyl acetate extracts of the entire plant of Arbutus unedo led to the isolation of a new sterol, 7beta-hydroxystigmast-4-en-3-one (1), and nine known compounds of the flavan, steroid, and terpenoid types. The structure of 1 was determined by spectroscopic data interpretation in combination with molecular modeling calculations. The absolute stereochemistry of C-7 was assigned as S for compound 1 based on the obtained CD spectral data. Activity in the JB6 cell transformation assay was found for pomolic acid 3-acetate (4). All isolates obtained were evaluated in a cyclooxygenase-2 (COX-2) inhibition assay.

References

Apr 1, 1992·Journal of Ethnopharmacology·V De FeoF Senatore
Nov 1, 1987·Journal of Ethnopharmacology·J L RíosA Villar
Sep 23, 2000·Journal of Natural Products·L C ChangA D Kinghorn
Feb 24, 2001·Drug Metabolism and Drug Interactions·M Cuendet, J M Pezzuto

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Citations

Jun 24, 2008·Natural Product Research·Enrico SanjustAntonio Rescigno
Apr 1, 2014·Phytochemistry·Jane NamukobeJohn D Kabasa
Oct 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria G MiguelMaria D Antunes
Jun 26, 2015·International Journal of Molecular Sciences·Daniela F S FonsecaSílvia M Rocha
Apr 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ivo OliveiraPaula Baptista
Aug 8, 2007·Journal of Ethnopharmacology·Mohammed El HaouariGinés M Salido
Sep 21, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Birgit WaltenbergerHermann Stuppner
Nov 30, 2014·Human Molecular Genetics·Diana MacedoCláudia N Santos
Oct 11, 2012·Natural Product Reports·Jorge A R SalvadorYongkui Jing
Dec 26, 2018·Critical Reviews in Food Science and Nutrition·Maria Concetta TenutaBrigitte Deguin

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Datasets Mentioned

BETA
PR-55025

Methods Mentioned

BETA
NMR
column chromatography

Software Mentioned

PC Model
PCMODEL

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