Potential Common Pathogenic Pathways for the Left Ventricular Noncompaction Cardiomyopathy (LVNC).

Pediatric Cardiology
Ying LiuWeinian Shou

Abstract

Ventricular trabeculation and compaction are two essential morphogenetic events for generating a functionally competent ventricular wall. A significant reduction in trabeculation is usually associated with hypoplastic wall and ventricular compact zone deficiencies, which commonly leads to embryonic heart failure and early embryonic lethality. In contrast, the arrest of ventricular wall compaction (noncompaction) is believed to be causative to the left ventricular noncompaction (LVNC), a genetically heterogeneous disorder and the third most common cardiomyopathy among pediatric patients. After critically reviewing recent findings from genetically engineered mouse models, we suggest a model which proposes that defects in myofibrillogenesis and polarization in trabecular cardiomyocytes underly the common pathogenic mechanism for ventricular noncompaction.

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Citations

Jul 11, 2020·Current Cardiology Reports·Josef Finsterer, Claudia Stöllberger
Feb 8, 2020·Current Oncology Reports·Kyle WierzbickiCarl Koschmann
Jul 26, 2019·Pediatric Cardiology·Caroline ChoquetLucile Miquerol
Mar 15, 2021·Heart Failure Reviews·Sofie RohdeKadir Caliskan
May 18, 2021·Frontiers in Genetics·Hugo R MartinezJohn L Jefferies
Jun 18, 2019·Pathology, Research and Practice·Fei CaoLixue Yin

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