Potential delay in the diagnosis of vulvar cancer and associated risk factors in women treated in German gynecological practices

Oncotarget
Jennifer MuigaiMatthias Kalder

Abstract

The goal of this study was to estimate a potential delay in the diagnosis of vulvar cancer and identify associated risk factors in women treated in gynecological practices in Germany. The current study sample included 1,652 women from 218 gynecological practices who received an initial diagnosis of vulvar cancer (ICD 10: C51) between January 2000 and December 2015 (index date). After applying several exclusion criteria, 505 non-cancer controls were matched (1:1) to 505 vulvar cancer cases based on age, health insurance status, and index date. The primary outcome was the delay in vulvar cancer diagnosis in women who had received an initial diagnosis of diseases of Bartholin's gland, inflammation of vagina and vulva, or other specified noninflammatory disorders of vulva, including atrophy, hypertrophy, and cyst. A logistic regression model was used to estimate the association between vulvar cancer and pre-defined diagnoses. The mean age was 60.8 years (SD = 15.6 years), and 4.8% of women had private health insurance coverage. Inflammation of vagina and vulva was diagnosed 328 days (SD = 95 days) prior to the detection of vulvar cancer. This delay was 186 days (SD = 196 days) in patients affected by diseases of Bartholin's gland a...Continue Reading

References

May 1, 1997·Gynecologic Oncology·C Rosén, H Malmström
Mar 21, 1998·British Journal of Obstetrics and Gynaecology·C A RhodesM I Shafi
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J. Menczer
Jan 9, 2008·The Journal of Sexual Medicine·Lara J BurrowsAndrew T Goldstein
Apr 15, 2008·Critical Reviews in Oncology/hematology·H P van de NieuwenhofJ A de Hullu
Mar 17, 2009·American Journal of Obstetrics and Gynecology·Grainger S LanneauPatricia L Judson
Oct 15, 2009·International Journal of Clinical Pharmacology and Therapeutics·H BecherD Schröder-Bernhardi
May 27, 2010·The Journal of Sexual Medicine·Comfort Ibe, James A Simon
Jul 28, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mai Partridge VandborgOle Mogensen
Feb 15, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Waltraud AnemüllerKatharina Kelling
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Neville F HackerJacobus van der Velden
Sep 8, 2016·Oman Medical Journal·Mohammed H Al-Azri

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Citations

Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Linda J Rogers, Mauricio A Cuello
Jan 6, 2021·Menopause : the Journal of the North American Menopause Society·Annekathryn Goodman
Feb 4, 2021·Case Reports in Medicine·Nawaraj AdhikariMeekoo Dhar

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