Potential drug interaction between warfarin and linezolid

Internal Medicine
Yoshiro SakaiHiroshi Watanabe

Abstract

Warfarin is known to interact with many drugs; however, there are currently no descriptions of an interaction with linezolid in the literature. It was recently brought to our attention, however, that several warfarin-medicated patients have experienced an increase in the prothrombin time international normalized ratio (PT-INR) following the administration of linezolid. We therefore performed a retrospective survey in order to investigate the possibility of an interaction between warfarin and linezolid. The survey items included age, gender, underlying disease, type of surgery, type of infectious disease, duration of linezolid administration, laboratory values and the dose of warfarin. The PT-INR was observed over time before treatment and at days 4 or 5 and 10, completion and one week after the end of concomitant therapy. Patients The subjects included six patients who were recovering from recent heart-related surgery. The PT-INR increased from 1.62±0.32 before concomitant linezolid administration to 3.00±0.83 at day 4 or 5 after concomitant administration (p<0.01) and significantly decreased from 1.65±0.45 at the completion of the regimen to 1.26±0.1 one week later (p<0.05). With respect to the relationship between the dose of...Continue Reading

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Citations

Oct 13, 2015·Expert Opinion on Drug Metabolism & Toxicology·Antonios DourosRalf Stahlmann
Mar 17, 2016·Expert Opinion on Drug Metabolism & Toxicology·Dario CattaneoMichael Neely
Oct 25, 2017·Clinical Pharmacokinetics·Claire RogerLaurent Muller
Oct 28, 2019·Therapeutic Drug Monitoring·Gauri G RaoUNKNOWN IATDMCT Antimicrobial Scientific Committee
Jul 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takafumi NakanoHidetoshi Kamimura
Jan 14, 2020·Case Reports in Critical Care·Rashmi MishraTrupti Vakde

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