Potential effect of using ABO-compatible living-donor liver transplantation

Transplantation Proceedings
Eleazar ChaibEduardo Massad

Abstract

Liver transplantation increased 1.84-fold from 1988 to 2004. However, the number of patients on the waiting list for a liver increased 2.71-fold, from 553 to 1500. We used a mathematical equation to analyze the potential effect of using ABO-compatible living-donor liver transplantation (LDLT) on both our liver transplantation program and the waiting list. We calculated the prevalence distribution of blood groups (O, A, B, and AB) in the population and the probability of having a compatible parent or sibling for LDLT. The incidence of ABO compatibility in the overall population was as follows: A, 0.31; B, 0.133; O, 0.512; and AB, 0.04. The ABO compatibility for parent donors was blood group A, 0.174; B, 0.06; O, 0.152; and AB, 0.03; and for sibling donors was A, 0.121; B, 0.05; O, 0.354; and AB, 0.03. Use of LDLT can reduce the pressure on our liver transplantation waiting list by decreasing its size by at least 16.5% at 20 years after its introduction. Such a program could save an estimated 3600 lives over the same period.

References

Jun 15, 2004·Transplantation Proceedings·T Bacchella, M C C Machado
Jan 3, 2006·Transplantation Proceedings·E Chaib, E Massad
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P MuiesanN Heaton
Nov 28, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Eleazar Chaib, Eduardo Massad
Feb 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Salvatore GruttadauriaBruno Gridelli
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·S NadalinC E Broelsch
May 13, 2008·Gastroenterology·Robert S Brown

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