Potential effects of chlorpyrifos on fetal growth outcomes: implications for risk assessment.

Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Pamela J MinkAbby A Li

Abstract

Chlorpyrifos (CPF) is one of the most widely used organophosphate insecticides in the United States. By December 2000, nearly all residential uses were voluntarily canceled, so that today, CPF is only used to control insect pests on a variety of crops. Periodic review of the potential effects of CPF on all developmental outcomes is necessary in the United States because the Food Quality Protection Act mandates special consideration of risk assessments for infants and children. This article reviews epidemiologic studies examining the association of potential CPF exposure with growth indices, including birth weight, birth length, and head circumference, and animal studies focusing on related somatic developmental endpoints. It differs from earlier reviews by including an additional cohort study and providing in-depth systematic evaluation of the patterns of association across different studies with respect to specificity of biomarkers for CPF, consistency, dose response, strength of association, temporality, and biological plausibility (Hill 1965), as well as consideration of the potential role of effect modification and bias. The review did not identify any strong associations exhibiting consistent exposure-response patterns tha...Continue Reading

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Citations

Jun 20, 2013·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Carol J BurnsAbby A Li
Jun 25, 2014·Environmental Toxicology and Pharmacology·Graciela ChiapellaGladis Magnarelli
Jul 23, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chengquan LuJing Shao
Jun 28, 2016·Accountability in Research·Kristin Shrader-Frechette, Christopher ChoGlueck
Feb 3, 2015·Journal of Pediatric Gastroenterology and Nutrition·Claire Joly CondetteHafida Khorsi-Cauet
Jun 4, 2018·Biochemical and Biophysical Research Communications·Isaac A AdedaraEbenezer O Farombi

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Methods Mentioned

BETA
cesarean section

Software Mentioned

MEDLINE
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