PMID: 15221702Jan 1, 1987Paper

Potential effects of glucocorticoids on serum iron concentration in dogs

Veterinary Clinical Pathology
J W HarveyC L Chen

Abstract

Prednisone was give norally(2mg/kg b.i.d.) to seven healthy mixed breed dogs for 3 consecutive days. Serum iron concentration increased significantly (p < 0.05) from 142 +/- 26 micro g/dl (mean +/- SE) before a drug adminis- tration on Day 0 to a maximum of 307 +/- 47 micro g/dl on Day 2, and returned to the Day 0 value by Day 5. Mean total iron binding capacity did not vary more than 25% from the Day 0 value during the 9 day long study. The percent saturation of transferrin with iron increased from 33 +/- 6% on Day 0 to a maximum of 71 +/- 9% on Day 3. This determination had decreased to 34 +/- 3% on Day 5. No statistically significant changes occurred in these parameters studied in six control dogs that were not given the drug. To determine whether serum iron concentration might be correlated with endogenous serum cortisol concentration, these tests were determined in serum collected from nine dogs at 7 a.m., 3 p.m., and 11 p.m. each day for 3 consecutive days. Serum iron concentration was lower at 7 a.m. (147 +/- 9 micro g/dl) than at 3 p.m. (164 +/- 9 micro g/dl) or 11 p.m. (159 +/- 10 micro g/dl). Likewise serum cortisol was lower at 7 a.m. (1.29 +/- 0.18 micro g/dl) than at 3 p.m. (1.49 +/- 0.19 micro g/dl) or 11 p.m. (1....Continue Reading

References

Jul 1, 1968·The Journal of Endocrinology·A RijnberkJ H Thijssen
Mar 1, 1973·The British Veterinary Journal·J R Campbell, C Watts
Apr 1, 1967·The Journal of Clinical Endocrinology and Metabolism·D N OrthG W Liddle
Mar 1, 1983·Annals of Internal Medicine·M Feldman, L R Schiller
Oct 1, 1984·Clinical Biochemistry·T J Wilke, D A Hirning
Aug 1, 1983·British Journal of Haematology·T E PetoD J Weatherall
Nov 1, 1982·The Journal of Dermatologic Surgery and Oncology·J A TorokH Williams

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Citations

Jun 22, 2010·Journal of Veterinary Internal Medicine·K R FriedrichsK M Young
Aug 28, 2010·Veterinary Medicine International·Veronica MarchettiGiovanni Cardini
Jul 24, 2013·The Journal of Veterinary Medical Science·Seishiro ChikazawaSeiichi Higuchi
Apr 19, 2011·Journal of the American Animal Hospital Association·Jennifer L McCown, Andrew J Specht
Dec 4, 2019·Frontiers in Veterinary Science·Margaret L MusserChad M Johannes

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