Potential effects of stress in critical illness through the role of stress neuropeptides

Nursing in Critical Care
Elizabeth D E PapathanassoglouAndreas Karabinis

Abstract

To critically review evidence on the hypothesis that the multitude of cognitive and psychological stressors perceived by critically ill individuals may contribute to the development of pathophysiologic sequlae through modulation of the levels of stress neuropeptides. Critically ill individuals experience high levels of stress and intense adverse emotions. Although psychological stress has long been recognized as a factor in disease, and despite the nursing tenet on the importance of patients' psychological responses, in critical care, the potential physiologic effects of stress have received little attention. DESIGN, METHODS: Narrative critical review. Databases searched included Medline, CINAHL, PubMed and the Cochrane Library. Evidence on the role of stress neuropeptides and pertinent findings in critically ill individuals are reviewed. Limbic and extra-limbic brain structures along with specific stress neuropeptides [corticotrophin releasing hormone (CRH), adrenocorticotropin hormone (ACTH), neuropeptide Y , vasopressin, prolactin, oxytocin, substance P, cholecystokinin, endorphins, enkephalins, somatostatin, noradrenaline, melatonin] are involved in emotional and stress responses. Research evidence indicates that stress neu...Continue Reading

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Citations

Jan 16, 2016·Journal of Clinical Nursing·Claire Minton, Lesley Batten
Dec 20, 2011·Hormones and Behavior·Adam S Smith, Zuoxin Wang
Apr 5, 2016·Nursing in Critical Care·Elizabeth Papathanassoglou, Tanya Park
Aug 27, 2015·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Rong-Fang HuXiao-Ying Jiang
Apr 4, 2017·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Maria HadjibalassiElizabeth Papathanassoglou
Jul 10, 2012·Biological Research for Nursing·Elizabeth D E Papathanassoglou, Meropi D A Mpouzika
Nov 2, 2014·Biological Research for Nursing·Elizabeth D E PapathanassoglouMaria N Karanikola
Jul 22, 2010·Nursing in Critical Care·Julie Scholes, John Albarran
Mar 3, 2021·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Elizabeth Kusi-AppiahElizabeth Papathanassoglou
Sep 25, 2012·The Journal of Physical Chemistry. B·Olivier MozziconacciChantal Houée-Levin

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