Potential epigenetic mechanism in non-alcoholic Fatty liver disease

International Journal of Molecular Sciences
Chao SunLiang Qiao

Abstract

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in the liver. It ranges from simple steatosis to its more aggressive form, non-alcoholic steatohepatitis (NASH), which may develop into hepatic fibrosis, cirrhosis, or hepatocellular carcinoma (HCC) if it persists for a long time. However, the exact pathogenesis of NAFLD and the related metabolic disorders remain unclear. Epigenetic changes are stable alterations that take place at the transcriptional level without altering the underlying DNA sequence. DNA methylation, histone modifications and microRNA are among the most common forms of epigenetic modification. Epigenetic alterations are involved in the regulation of hepatic lipid metabolism, insulin resistance, mitochondrial damage, oxidative stress response, and the release of inflammatory cytokines, all of which have been implicated in the development and progression of NAFLD. This review summarizes the current advances in the potential epigenetic mechanism of NAFLD. Elucidation of epigenetic factors may facilitate the identification of early diagnositic biomarkers and development of therapeutic strategies for NAFLD.

References

Aug 7, 2002·The Journal of Nutrition·Mihai D Niculescu, Steven H Zeisel
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
Oct 17, 2003·The Journal of Physiology·Julio F Turrens
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorPatrick Colin
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eduardo FassioCristina Longo
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Farrell, Claire Z Larter
Feb 2, 2006·The Journal of Clinical Endocrinology and Metabolism·Dominik G HaiderBernhard Ludvik
Feb 18, 2006·Nature Reviews. Drug Discovery·Christine B Yoo, Peter A Jones
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Deepak N AmarapurkarUNKNOWN Asia-Pacific Working Party on NAFLD
Jun 3, 2008·Journal of Molecular Endocrinology·Kjersti M Aagaard-TilleryRobert H Lane
Jul 5, 2008·Clinical Reviews in Allergy & Immunology·Frank TackeChristian Trautwein
Aug 7, 2008·Journal of Hepatology·Janus P OngZobair M Younossi
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Dec 4, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nila RafiqZobair M Younossi
Jan 28, 2009·Alcoholism, Clinical and Experimental Research·Angela M ZivkovicCharles H Halsted
Apr 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S M MalikJ Ahmad
Nov 17, 2009·QJM : Monthly Journal of the Association of Physicians·J K DowmanP N Newsome
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Julieta CarabelliSilvia Sookoian
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri
Aug 24, 2010·Molecular Genetics and Metabolism·Almudena LombaFermín I Milagro
Oct 1, 2010·Trends in Endocrinology and Metabolism : TEM·Kathryn J MooreCarlos Fernández-Hernando
Oct 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvia SookoianCarlos J Pirola
Oct 20, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anna AlisiValerio Nobili
Oct 26, 2010·Endocrine Reviews·Z HochbergK Albertsson-Wikland
Mar 29, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiManirath Srishord
Apr 19, 2011·Toxicology Mechanisms and Methods·Kimberley D Bruce, Felino R Cagampang
Apr 19, 2011·Best Practice & Research. Clinical Gastroenterology·Vincent Zimmer, Frank Lammert
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yasar ColakFeruze Yilmaz Enc
Jun 3, 2011·Journal of Lipid Research·Sophie C CazanaveGregory J Gores
Jul 19, 2011·The Journal of Nutritional Biochemistry·Menno HoekstraTheo J C Van Berkel

❮ Previous
Next ❯

Citations

Sep 23, 2016·International Journal of Molecular Sciences·Alessandra CaligiuriFabio Marra
Nov 28, 2016·Molecular Aspects of Medicine·Jooho LeeSang-Woon Choi
Jan 2, 2018·World Journal of Gastroenterology : WJG·Xiao-Lin LiuJian-Gao Fan
Feb 2, 2019·Nutrition Research Reviews·Sabrina CampisanoAndrea N Chisari
Jun 20, 2020·Expert Review of Gastroenterology & Hepatology·Alan Eduardo Botello-ManillaNatalia Nuño-Lámbarri
Jul 3, 2020·Nutrients·Joseph BoachiePonnusamy Saravanan
Sep 8, 2020·Expert Review of Gastroenterology & Hepatology·Letícia F RamosKaren C M Moraes
Nov 12, 2015·World Journal of Gastroenterology : WJG·Omar Ramos-LopezArturo Panduro
Sep 16, 2016·Journal of Digestive Diseases·Xiao Lin LiuJian Gao Fan
Jun 20, 2019·Nutrition Research and Practice·Sangwon ChungHyo-Kyoung Choi
Aug 6, 2019·Current Hepatology Reports·Mazen Noureddin, Arun J Sanyal
Feb 2, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kenichi Watanabe
Jul 18, 2018·Biological Trace Element Research·Eleni AsprouliNick Kalogeropoulos
Nov 20, 2016·Journal of Digestive Diseases·Wen Ji ChenYong Jian Zhou
Nov 5, 2020·International Journal of Molecular Sciences·Jeongeun Hyun, Youngmi Jung
Dec 2, 2020·International Journal of Molecular Sciences·Pradeep Kumar RajanJuan Sanabria
Jun 14, 2020·Annals of Hepatology·Guillermo Nahúm López-SánchezNatalia Nuño-Lámbarri
Mar 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nalini SodumC Mallikarjuna Rao
Feb 1, 2019·Journal of Inorganic Biochemistry·C GerosaG Faa
Jun 11, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Xinting PanXian-E Peng

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation
acetylation
immunoprecipitation
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.