Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats

Experimental Gerontology
Chi-Chang HuangWan-Teng Lin

Abstract

In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise. Thirty 18-month-old male Sprague-Dawley rats were randomly divided into four groups: sedentary control (SC); sedentary control with L-Arg treatment (SC+Arg); exhaustive exercise (E); and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg performed an exhaustive running test on a treadmill. The mean duration of exercise differed significantly between groups E and E+Arg (51+/-6 versus 63+/-3min). Results showed significant increases in xanthine oxidase (XO) and myeloperoxidase (MPO) activities and in lipid peroxidation end-product (malondialdehyde, MDA) levels of myocardial, muscular, hepatic, pulmonary, and renal tissues of exercised rats compared with SC and SC+Arg rats. The increased XO and MPO activities and MDA levels significantly decreased in exercised rats that were fed a diet supplemented with L-Arg. We also found that L-Arg supplementation prevented exhaustive exercise-induced elevations of plasma aminotransferase activity, and lactate and uric acid levels in aging r...Continue Reading

References

Dec 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A Brooks, T P White
Apr 1, 1992·Molecular and Cellular Biochemistry·C T KumarP Reddanna
May 1, 1990·Journal of Pharmacological Methods·C SchierwagenC Lundberg
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·S M SomaniL P Rybak
May 1, 1995·The American Journal of Physiology·P M HassounJ J Lanzillo
Sep 1, 1994·Free Radical Research·M FukahoriH Okino
Mar 2, 1994·Biochemical Pharmacology·L L Ji, E W Mitchell
Jul 1, 1993·The American Journal of Physiology·R A FieldingJ G Cannon
Apr 1, 1996·Journal of Applied Physiology·A N BelcastroD A Raj
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·A Frankiewicz-JóźkoB Sieradzan-Gabelska
Feb 28, 1998·Pflügers Archiv : European journal of physiology·Z RadákS Goto
Jul 3, 1998·European Journal of Applied Physiology and Occupational Physiology·T AshtonJ R Peters
Sep 29, 1998·Mechanisms of Ageing and Development·A Navarro-Arévalo, M J Sánchez-del-Pino
Feb 8, 2000·Luminescence : the Journal of Biological and Chemical Luminescence·M YamadaK Sugawara
Jun 27, 2000·The Journal of Nutrition·B Lewis, B Langkamp-Henken
Aug 2, 2000·The American Journal of Clinical Nutrition·P M Clarkson, H S Thompson
Jan 25, 2002·Annals of the New York Academy of Sciences·L L Ji
Apr 27, 2002·Annals of the New York Academy of Sciences·Michael B Reid, William J Durham
Sep 7, 2002·International Journal of Sports Medicine·A SchaeferJ Lonsdorfer
May 9, 2003·European Journal of Applied Physiology·Vladimir I MorozovVictor A Rogozkin
Sep 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·A R Judge, S L Dodd
Oct 28, 2003·Molecular and Cellular Biochemistry·De-Sheng XiaoLiwei Lu
Jun 24, 2004·Nutrition·Wayne W Campbell, Rachel A Geik
Oct 7, 2004·The Journal of Nutrition·Douglas Paddon-JonesRobert R Wolfe
Feb 24, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Pushpalatha KakarlaSathyavelu Reddy Kesireddy
Jun 4, 2005·The Journal of Physiology·Mari-Carmen Gomez-CabreraJose Viña
Aug 18, 2005·American Journal of Physiology. Endocrinology and Metabolism·G K McConellG D Wadley
Jun 23, 2006·European Journal of Applied Physiology·Vladimir I MorozovMichael I Kalinski
Nov 23, 2006·Antioxidants & Redox Signaling·Agnieszka SiomekRyszard Olinski
Mar 9, 2007·American Journal of Physiology. Cell Physiology·Sharon Judge, Christiaan Leeuwenburgh

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Citations

Dec 17, 2011·Plant Foods for Human Nutrition·André Luiz Machado VianaFernanda Borges de Araujo Paula
Oct 15, 2011·The British Journal of Nutrition·Yu-Cun NiuYing Li
Feb 6, 2010·Critical Care Medicine·W Darlene ReidR Luke Harris
May 4, 2012·BMC Complementary and Alternative Medicine·Laila M FaddahMuhammad Atteya
Sep 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Manuel Rosety-RodriguezFrancisco Javier Ordonez
Jan 22, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chieh-Chung LiuHsiao-Chuan Wen
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·O F AranedaM Tuesta
Jun 30, 2012·Phytotherapy Research : PTR·Muaz BelviranlıSadık Büyükbaş
May 1, 2016·Journal of Pharmacological Sciences·Tsung-Ming LeeNen-Chung Chang
Mar 5, 2015·Antioxidants & Redox Signaling·Anne D HafstadEllen Aasum
Nov 5, 2014·European Journal of Applied Physiology·Roy J Shephard, Nathan Johnson
Sep 17, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sun-Young NamHyun-Ja Jeong
Feb 9, 2017·Free Radical Research·Rômulo Pillon BarcelosGuilherme Bresciani
Feb 24, 2015·Critical Care Medicine·Neil E HillMervyn Singer
Feb 29, 2020·Research Quarterly for Exercise and Sport·Edenilson Pinto da SilvaRafael Herling Lambertucci
Aug 13, 2020·Biomedicines·Jessica GambardellaValentina Trimarco
May 31, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Chien-Chang ChenTsung-Ming Lee
Sep 12, 2017·The Journal of Veterinary Medical Science·Wen-Chyuan ChenFu-An Chen
Jun 27, 2017·Scandinavian Journal of Medicine & Science in Sports·S R L MoraisS H P Oliveira
Jul 25, 2009·Journal of Pineal Research·C VenerosoPilar S Collado
May 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Qiang HuangPei-Bo Li
Aug 11, 2020·European Journal of Applied Physiology·Felipe Contreras-BriceñoOscar F Araneda
Dec 17, 2021·Journal of Food Biochemistry·Syafiq Zikri SallehMohd Sabri Pak Dek

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