Abstract
The present study was the first to investigate the potential of saliva in community diagnosis of the major human intestinal nematode infections, Trichuris trichiura, Ascaris lumbricoides, and the hookworms. Immunoglobulin G (IgG) antibodies specific to parasite antigens were quantified in saliva samples of 187 individuals (all ages) from a St Lucian community, and 120 school-aged children from Tanga region, Tanzania, and relationships with current infection status (determined by numbers of parasite eggs in stool) were examined. For T. trichiura infection, the age relationships of parasite-specific salivary IgG antibodies mirrored those of infection intensity at the community level. Within both areas, children with current T. trichiura infection exhibited significantly higher anti-T. trichiura salivary IgG responses than uninfected children. Similar trends were apparent for A. lumbricoides and hookworm infections, though not to a level of statistical significance. Comparison of mean T. trichiura infection levels and antibody responses in age-matched children from St Lucia and Tanzania suggested that measurement of parasite-specific salivary IgG may have potential as a marker of transmission intensity at the community level.
References
Oct 1, 1992·Parasitology·C S NeedhamA E Bianco
Nov 1, 1992·Parasite Immunology·D I PritchardA E Keymer
Mar 1, 1992·Veterinary Parasitology·A KinderP S Craig
Jan 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·M BradleyG F Medley
Jul 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·D I PritchardA E Keymer
Nov 1, 1991·Parasite Immunology·D A BundyA E Bianco
Sep 1, 1991·Parasite Immunology·J E LillywhiteA E Bianco
Jul 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·M FeldmanA Flisser
Sep 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A Bundy
Aug 1, 1989·Journal of Medical Virology·J V ParryP P Mortimer
Jul 11, 1987·Lancet·J V ParryP P Mortimer
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·R H MeakinsF Carswell
Dec 1, 1993·Parasite Immunology·C S NeedhamD A Bundy
Sep 1, 1995·Parasitology·D R PalmerK S Anwar
Jan 1, 1995·Parasite Immunology·J E LillywhiteA E Bianco
Jan 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·R S de Azevedo NetoE Massad
May 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A Bundy
May 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·C S Needham, J E Lillywhite
Sep 20, 1993·Annals of the New York Academy of Sciences·J Mestecky
Sep 20, 1993·Annals of the New York Academy of Sciences·J V Parry
Sep 20, 1993·Annals of the New York Academy of Sciences·R M ClemmonsJ Shands
Mar 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·C Nokes, D A Bundy
Citations
Jan 1, 2011·Tropical Parasitology·T SunitaM L Dubey
Nov 10, 2015·Current Tropical Medicine Reports·Poppy H L Lamberton, Peter M Jourdan
Oct 3, 2014·BioMed Research International·Radha S P MalonEmma P Córcoles
May 5, 2001·Expert Opinion on Pharmacotherapy·V St Georgiev
Mar 6, 2007·Acta Tropica·T SunitaNancy Malla
May 1, 2009·Mucosal Immunology·P J Cooper
Jun 28, 2011·Parasitology International·Prajak SawangsodaPaiboon Sithithaworn