Potential for elimination of SAR-CoV-2 through vaccination as inspired by elimination of multiple influenza viruses through natural pandemics or mass vaccination

Journal of Medical Virology
Ji-Ming ChenJi-Wang Chen

Abstract

The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has claimed many lives worldwide. To combat the pandemic, multiple types of vaccines are under development with unprecedented rapidity. Theoretically, future vaccination against COVID-19 may fall into long-term costly guerrilla warfare between SARS-CoV-2 and humans. Elimination of SARS-CoV-2 through vaccination to avoid the potential long-term costly guerrilla warfare, if possible, is highly desired and worth intensive consideration. Human influenza pandemics emerging in 1957, 1968, and 2009 established strong global herd immunity and led to the elimination of three human influenza viruses, which circulated worldwide for years before the pandemics. Moreover, both clade 7.2 of subtype H5 highly pathogenic avian influenza virus and subtype H7N9 avian influenza virus circulated in poultry in China for years, and they have been virtually eliminated through mass vaccination in recent years. These facts suggest that the rapid establishment of global herd immunity through mass vaccination using an appropriate vaccine could eliminate SARS-CoV-2. The coming 2 years are a golden time for elimi...Continue Reading

References

Sep 1, 2011·MBio·Peter Palese, Taia T Wang
Nov 25, 2014·Emerging Infectious Diseases·Qing-Xia MaJi-Ming Chen
Nov 11, 2018·Science China. Life Sciences·Xianying ZengHualan Chen
Apr 11, 2020·Nature Reviews. Drug Discovery·Tung Thanh LeStephen Mayhew
Apr 13, 2020·Research in Veterinary Science·Nicola DecaroCanio Buonavoglia
Apr 30, 2020·Nature·Ewen Callaway
May 15, 2020·PloS One·Wooyoung Lim, Pengfei Zhang

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Citations

Aug 25, 2020·Journal of Medical Virology·Ji-Ming Chen
Oct 21, 2021·Environmental Science and Pollution Research International·Shih-An ChangYu-Sheng Chen

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