Potential for erroneous interpretation of poisoning outcomes due to changes in National Poison Data System reporting

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
B AndersonW Klein-Schwartz

Abstract

In 2006, the annual report of poison centers in the United States changed the method of reporting profiles for generic substance categories from all exposures to single-substance exposures only. The objective of this study is to describe the potential impact of this reporting change on longitudinal analysis of outcomes. Generic substance categories with data available for all years of the study were manually extracted from Table 22 of the National Poison Data System (NPDS) annual reports for 2002-2007. For each generic substance category, the following data were extracted for each of the 6 years: total number of substance mentions (2002-2005) or single-substance exposures (2006-2007), reason (unintentional or intentional), pediatric exposures (children age <6 years), and outcomes of major effect and death. Data were compared using descriptive analysis (Wilcoxon signed-rank test) and negative binomial regression. There were 65 generic substance categories (30 drug categories and 35 nondrug categories) that had data in all study years. For drug categories the average annual number of reported deaths by substance category decreased by 80.8%, from 2,229 in year 2002-2005 to 428 after the 2006 reporting change (p < 0.0001). The aver...Continue Reading

References

Oct 3, 2003·The American Journal of Emergency Medicine·William A WatsonMary E May
Oct 19, 2004·The American Journal of Emergency Medicine·William A WatsonDouglas Borys
Sep 6, 2005·The American Journal of Emergency Medicine·William A WatsonKathleen M Wruk
Oct 4, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Melisa W LaiKathleen M Wruk
Dec 29, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alvin C BronsteinStuart E Heard
Dec 10, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alvin C BronsteinUNKNOWN American Association of Poison Control Centers

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Citations

Sep 27, 2014·Pharmacoepidemiology and Drug Safety·Alex M SecoraGerald J Dal Pan
May 11, 2012·The American Journal of Drug and Alcohol Abuse·Mathias B Forrester, Tracy Haywood
Aug 4, 2012·Human & Experimental Toxicology·M B ForresterA Young
Jan 25, 2020·Clinical Pediatrics·James B LeonardWendy Klein-Schwartz
Oct 2, 2012·Pediatric Emergency Care·Mathias B Forrester

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