Potential for misclassification of mild cognitive impairment: a study of memory scores on the Wechsler Memory Scale-III in healthy older adults

Journal of the International Neuropsychological Society : JINS
Brian L BrooksHoward H Feldman

Abstract

The psychometric criterion of mild cognitive impairment (MCI) generally involves having an unusually low score on memory testing (i.e., -1.5 SDs). However, healthy older adults can obtain low scores, particularly when multiple memory measures are administered. In turn, there is a substantial risk of psychometrically misclassifying MCI in healthy older adults. This study examined the base rates of low memory scores in older adults (55-87 years; n = 550) from the Wechsler Memory Scale-Third Edition (WMS-III; Wechsler, 1997b) standardization sample. The WMS-III consists of four co-normed episodic memory tests (i.e., Logical Memory, Faces, Verbal Paired Associates, and Family Pictures) that yield eight age- and demographically-adjusted standard scores (Auditory Recognition and Working Memory tests not included). When the eight age-adjusted scores were examined simultaneously, 26% of older adults had one or more scores at or below the 5th percentile (i.e., -1.5 SDs). On the eight demographically- adjusted scores, 39% had at least one score at or below the 5th percentile. There was an inverse relationship between intellectual abilities and prevalence of low memory scores, particularly with the age-adjusted WMS-III scores. Understandi...Continue Reading

References

May 1, 1994·Neurology·R C PetersenE G Tangalos
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Aug 19, 2000·The Clinical Neuropsychologist·B A MarcopulosH R Brashear
Mar 23, 2001·The Clinical Neuropsychologist·H Tuokko, R J Frerichs
Sep 29, 2001·Journal of the International Neuropsychological Society : JINS·H G TaylorC Burant
Apr 4, 2002·The Australian and New Zealand Journal of Psychiatry·Alexander Collie, Paul Maruff
Oct 24, 2002·Acta Psychiatrica Scandinavica·J BischkopfM C Angermeyer
Aug 14, 2003·Current Neurology and Neuroscience Reports·David A Bennett
Aug 27, 2003·Neurology·C A LuisR Duara
Apr 6, 2004·International Journal of Geriatric Psychiatry·Heather S Davis, Kenneth Rockwood
Jul 14, 2004·Neurology·Mary GanguliSteven T DeKosky
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Dec 29, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laura A RabinLeslie A Burton
Jul 16, 2005·The Clinical Neuropsychologist·Jennifer J Manly
Aug 9, 2005·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Francesco PanzaVincenzo Solfrizzi
Aug 9, 2005·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Howard H Feldman, Claudia Jacova
Oct 26, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J de RotrouA-S Rigaud
Nov 9, 2005·Dementia and Geriatric Cognitive Disorders·Giovanni RavagliaErminia Mariani
Mar 22, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·F PortetUNKNOWN MCI Working Group of the European Consortium on Alzheimer's Disease (EADC)
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
May 9, 2006·Dementia and Geriatric Cognitive Disorders·P AlexopoulosA Kurz
May 12, 2006·Journal of the American Geriatrics Society·Mariella ZanettiLuigi Bergamaschini
Aug 31, 2006·Dementia and Geriatric Cognitive Disorders·Kristine YaffeBruce Miller
Oct 28, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·David A LoewensteinRanjan Duara
Nov 25, 2006·Dementia and Geriatric Cognitive Disorders·David A LoewensteinRanjan Duara
Dec 1, 2006·International Journal of Geriatric Psychiatry·T GabryelewiczM Barcikowska
Dec 28, 2006·Neurology·A BusseS G Riedel-Heller
Mar 14, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Jennifer J Manly, Ruben J Echemendia
Mar 16, 2007·Dementia and Geriatric Cognitive Disorders·R PerriUNKNOWN Early Diagnosis Group of Italian Interdisciplinary Network on Alzheimer's Disease
Sep 14, 2007·The Clinical Neuropsychologist·L J RitchieH Tuokko

❮ Previous
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Citations

Jul 4, 2009·Journal of the International Neuropsychological Society : JINS·Brian L BrooksJames A Holdnack
Nov 6, 2009·Journal of the International Neuropsychological Society : JINS·David J LibonDenene M Wambach
Oct 26, 2012·Journal of the International Neuropsychological Society : JINS·Sarah E CookMichael Crowe
Jan 11, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Brian L Brooks
Apr 9, 2009·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Laura A RabinRobert B Santulli
Aug 25, 2011·The Clinical Neuropsychologist·Anthony P OdlandWiley Mittenberg
Apr 28, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laurence M BinderBrian L Brooks
Sep 15, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Brian L BrooksTravis White
Dec 18, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Brian L Brooks, Grant L Iverson
Feb 25, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Brian L BrooksGrant L Iverson
Jun 24, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kevin DuffSid E O'Bryant
Dec 15, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Susan VandermorrisEsther Strauss
May 18, 2011·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Jennifer A FoleySergio Della Sala
May 17, 2012·Dementia and Geriatric Cognitive Disorders Extra·Dina SilvaAlexandre de Mendonça
Feb 5, 2014·Journal of the International Neuropsychological Society : JINS·Mark W Bondi, Glenn E Smith
Oct 15, 2014·Brain Injury : [BI]·Grant L Iverson, Philip Schatz
May 7, 2013·The Medical Clinics of North America·John Harrison
Mar 15, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·John A SchinkaRanjan Duara
Nov 28, 2008·Neurobiology of Aging·Emma TerrièreKlaus P Ebmeier
Apr 5, 2013·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Norio MurayamaKiyoshi Sato
Aug 27, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Norio MurayamaKiyoshi Sato
Feb 18, 2014·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Shannon Z Klekociuk, Mathew J Summers
Jan 1, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Z Klekociuk, M J Summers
Jun 20, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Z KlekociukM J Summers
May 27, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Emily C EdmondsUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 25, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Melissa MathewsFrederick A Schmitt
Jun 19, 2015·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Robin C HilsabeckDustin Wahlstrom
Mar 19, 2015·Journal of the International Neuropsychological Society : JINS·Brandon E Gavett
Feb 3, 2015·The Clinical Neuropsychologist·Anthony P OdlandChristopher L Grote
Dec 21, 2014·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Brian J IvinsGrant L Iverson
Nov 1, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Henry BrodatyPerminder S Sachdev
Mar 4, 2014·Journal of Clinical and Experimental Neuropsychology·Shannon Zofia Klekociuk, Mathew James Summers
May 20, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Lindsay R ClarkSterling C Johnson
Sep 30, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Brian L BrooksGrant L Iverson
Dec 1, 2011·American Journal of Alzheimer's Disease and Other Dementias·Geoffrey TremontBrian R Ott
Nov 11, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Mike R SchoenbergNeil H Pliskin
Aug 25, 2011·Nature Reviews. Rheumatology·John G Hanly, John D Fisk

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