Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer

Carcinogenesis
Yun FengQingyi Wei

Abstract

The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To test this hypothesis, we used three large publically available pancreatic cancer genome-wide association study (GWAS) datasets (PanScan I, II/III and PanC4) to assess the associations of 7168 single nucleotide polymorphisms (SNPs) in a set of 62 genes of this pathway with pancreatic cancer risk in 8477 cases and 6946 controls of European ancestry. We identify 15 significant pancreatic cancer risk-associated SNPs in three genes (SMC2, ARHGEF7 and TP53) after correction for multiple comparisons by a false discovery rate < 0.20. Through further linkage disequilibrium analysis, SNP functional prediction and stepwise logistic regression analysis, we focused on three SNPs: rs3818626 in SMC2, rs79447092 in ARHGEF7 and rs9895829 in TP53. We found that these three SNPs were associated with pancreatic cancer risk [odds ratio (OR) = 1.12, 95% confidence interval (CI) = 1.07-1.17 and P = 2.20E-06 for the rs3818626 C allele; OR = 0.76, CI = 0.66-0.88 and P = 1.46E-04 for the rs79447092 A all...Continue Reading

References

Dec 1, 1991·British Journal of Cancer·C M BartonR C Williamson
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·E A Nigg
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Robert GrützmannHans Detlev Saeger
Jan 30, 2007·Molecular Cancer Research : MCR·Jingyan FuChuanmao Zhang
Sep 28, 2007·Nature Genetics·Matthew D MailmanStephen T Sherry
May 24, 2008·Advances in Experimental Medicine and Biology·Patrick SalaunClaude Prigent
Mar 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert R McWilliamsGloria M Petersen
Aug 18, 2009·The Oncologist·David S BossJan H M Schellens
Oct 29, 2009·JAMA : the Journal of the American Medical Association·Fay KastrinosSapna Syngal
Jan 23, 2010·Nature Reviews. Cancer·Juan-Manuel SchvartzmanRobert Benezra
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Magali OlivierPierre Hainaut
Mar 26, 2010·Current Biology : CB·Sarah L ThompsonDuane A Compton
Jul 6, 2010·American Journal of Human Genetics·Jimmy Z LiuStuart Macgregor
Jul 17, 2010·Bioinformatics·Randall J PruimCristen J Willer
Jan 22, 2011·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Ayelet Eppel BorgidaSteven Gallinger
May 16, 2012·Cancer Discovery·Nicholas J RobertsAlison P Klein
Sep 8, 2012·Genome Research·Alan P BoyleMichael Snyder
Nov 15, 2012·Current Opinion in Oncology·Daniel MenendezMichael A Resnick
May 2, 2013·Genes & Cancer·Ignacio Pérez de Castro, Marcos Malumbres
Jul 17, 2013·CA: a Cancer Journal for Clinicians·Christopher L WolfgangRalph H Hruban
Sep 17, 2013·Nature·Tuuli LappalainenEmmanouil T Dermitzakis
Dec 4, 2013·Nucleic Acids Research·Kimberly A TrykaMichael Feolo
Feb 4, 2014·Journal of Oncology·Ashraf MohamadkhaniAkram Pourshams
Aug 2, 2014·Nature Cell Biology·Ana R R MaiaRené H Medema
Aug 5, 2014·Nature Genetics·Brian M WolpinLaufey T Amundadottir
Nov 27, 2014·The EMBO Journal·Emad Heidary ArashLiliana Attisano
Dec 19, 2014·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Aniket Mishra, Stuart Macgregor
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Aug 1, 2015·Hematology/oncology Clinics of North America·Rachael Z Stolzenberg-Solomon, Laufey T Amundadottir
Jan 16, 2016·Cell Systems·Arthur LiberzonPablo Tamayo
Feb 26, 2016·Carcinogenesis·Xiaozheng KangUNKNOWN Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team

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