Potential Gene Therapy Towards Treating Neurodegenerative Disea ses Employing Polymeric Nanosystems

Current Gene Therapy
Prachi BangdeRatnesh Jain

Abstract

Recent integrated approaches involving nanotechnology and gene therapy have accelerated development of efficient drug delivery to the central nervous system (CNS). Neurodegenerative disorders are closely associated with genetic inheritance and mutation. Nanotechnology has allowed effective engineering of various such polymeric structures. Moreover, availability of a wide array of polymeric materials has enabled fabrication of biocompatible and biodegradable delivery vehicles. Our manuscript focuses on the ideal features and properties of polymeric nanoparticles that have enabled successful gene therapy for neurodegenerative disorders, as well as the challenges that are posing difficulties in their practical application. We have highlighted these aspects through examples of polymeric nanoparticles that have exhibited therapeutic promise in the treatment of neurological disorders and mutations. Complete cure of these diseases is a challenging task and gene therapy appears as a realistic approach for their treatment. Gene therapy allows effective replacement or suppression of faulty genes, thereby increasing chances for neuron survival and repair. However, successful delivery of naked genetic material to CNS faces severe obstacles...Continue Reading

Citations

Jul 29, 2020·Human Gene Therapy·Leonardo Fernandes Moutinho RochaFabio Batista Mota
Sep 6, 2019·Pharmaceutical Nanotechnology·Ranjit K HarwanshMd Akhlaquer Rahman
Mar 7, 2021·International Journal of Molecular Sciences·Farzane Sivandzade, Luca Cucullo
Apr 6, 2021·Frontiers in Bioengineering and Biotechnology·Maria Grazia TuponeAnnamaria Cimini
Feb 25, 2019·Advanced Drug Delivery Reviews·Caroline VissersHongjun Song

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