Sep 25, 2012

Potential immunotargets for Alzheimer's disease treatment strategies

Journal of Alzheimer's Disease : JAD
Patricia L FernándezK S Rao

Abstract

Alzheimer's disease (AD) exerts a profound burden on public health worldwide. AD etiology is unknown, and research to understand its underlying pathology has produced agents for the management of symptoms, but not a cure for the disease. Most AD drugs were developed in response to research implicating fibrillar amyloid-β (Aβ) in AD neuropathology but result in only modest short-term improvements in cognitive function, so there is agreement that additional targets need to be investigated. Evidence has implicated the immune system in AD and immunotherapy as a potential approach to AD treatment. Accumulation of microglia and astrocytes has been observed around Aβ deposits and several reports implicate inflammatory mediators in AD pathology. Importantly, Aβ deposition has been found in the brains of AD patients and in aged people without dementia, but signs of neuroinflammation are found only in AD patients and not in normal aged individuals. Animal models suggest a complex role for immunomodulators in AD, namely, these mechanisms are likely to promote the same pathogenic processes that gave rise to them. To date, clinical trials with anti-inflammatories and other immunoregulators have not been successful, but available data strong...Continue Reading

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Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Immune System
Immunomodulators
Exertion
APP protein, human
Immunologic Adjuvants
Pathogenic Organism
Anti-Inflammatory Agents
Brain
Astrocytes

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