Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease

Journal of Cardiovascular Development and Disease
Rashid MirShaheen Banu

Abstract

Purpose: Catechol-O-methyltransferase (COMT) plays a central role in DNA repair and estrogen-induced carcinogenesis. The nonsynonymous single nucleotide polymorphism (SNP) in exon 4 G > A or Val108 > 158Met or rs4680 G > A influences COMT enzyme activity. The three phenotypes of the COMT enzyme activities include COMT A/A with low enzyme activity, COMT A/G with medium enzyme activity and COMT G/G with high enzyme activity. The Met allele is associated with low enzymatic activity resulting in higher levels of prefrontal dopamine. Conversely, the Val allele is associated with high enzymatic activity and lower levels of prefrontal dopamine. The Met allele has been associated with several psychiatric disorders such as panic disorder. Many recent epidemiologic studies have investigated the association between the COMT Val158Met polymorphism and coronary artery diseases risk, but the results are inconclusive. Therefore our study was aimed to explore the association between COMT Val158Met polymorphism and the risk of coronary artery disease in India. Methology: This study was conducted on 100 clinically confirmed cases of coronary artery diseases and 100 healthy controls. COMT Val158Met genotyping was performed by allele-specific poly...Continue Reading

References

Jun 27, 2002·Expert Opinion on Pharmacotherapy·Claire Henchcliffe, Cheryl Waters
May 3, 2003·Carcinogenesis·Sara WedrénCecilia Magnusson
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jennifer A DohertyChu Chen
Apr 9, 2005·Annals of the New York Academy of Sciences·Jan VolavkaKaren Nolan
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Mary-Anne EnochDavid Goldman
Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Falk W LohoffWade H Berrettini
Aug 13, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Susan Garwood
May 20, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Esther WaltonStefan Ehrlich
Jul 19, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Kathryn T HallDaniel I Chasman
Aug 8, 2015·Developmental Psychobiology·Clancy BlairUNKNOWN Family Life Project Investigators
May 1, 2017·Reviews of Physiology, Biochemistry and Pharmacology·Pedro BastosLaura Ribeiro
Mar 30, 2018·Molecular Neuropsychiatry·Arpi MinassianWilliam Perry

❮ Previous
Next ❯

Methods Mentioned

BETA
percutaneous transluminal coronary angioplasty
electrophoresis

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.