Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrus

Frontiers in Systems Neuroscience
Helen E. Scharfman, Hannah L Bernstein

Abstract

The dentate gyrus (DG) is important to many aspects of hippocampal function, but there are many aspects of the DG that are incompletely understood. One example is the role of mossy cells (MCs), a major DG cell type that is glutamatergic and innervates the primary output cells of the DG, the granule cells (GCs). MCs innervate the GCs as well as local circuit neurons that make GABAergic synapses on GCs, so the net effect of MCs on GCs - and therefore the output of the DG - is unclear. Here we first review fundamental information about MCs and the current hypotheses for their role in the normal DG and in diseases that involve the DG. Then we review previously published data which suggest that MCs are a source of input to a subset of GCs that are born in adulthood (adult-born GCs). In addition, we discuss the evidence that adult-born GCs may support the normal inhibitory 'gate' functions of the DG, where the GCs are a filter or gate for information from the entorhinal cortical input to area CA3. The implications are then discussed in the context of seizures and temporal lobe epilepsy (TLE). In TLE, it has been suggested that the DG inhibitory gate is weak or broken and MC loss leads to insufficient activation of inhibitory neurons,...Continue Reading

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Citations

Jul 29, 2016·Nature Reviews. Neuroscience·Helen E Scharfman
Apr 12, 2016·The European Journal of Neuroscience·Xing Jin
Feb 17, 2018·Science·Helen E Scharfman
Mar 13, 2019·Social Psychiatry and Psychiatric Epidemiology·Clarissa BaratinCharles Agyemang
Jun 9, 2017·Reviews in the Neurosciences·Charles R Legéndy
Dec 3, 2016·Journal of Biomolecular Structure & Dynamics·Tajalli Ilm ChandelRizwan Hasan Khan
Aug 25, 2015·Nature Reviews. Cancer·Steven W ColeAnil K Sood
Feb 26, 2019·Frontiers in Molecular Neuroscience·Emmanuelle GoubertChristophe Pellegrino
Sep 20, 2019·Neural Plasticity·Hannah L BernsteinHelen E Scharfman
Sep 25, 2017·Neurobiology of Aging·Emrin Horgusluoglu-MolochUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)

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