Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria

Bioorganic & Medicinal Chemistry
P SrivastavaA P Bhaduri

Abstract

Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents.

References

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Citations

Oct 26, 2012·Journal of the Royal Society, Interface·Mona N RahmanZongchao Jia
Sep 2, 2008·Canadian Journal of Physiology and Pharmacology·Robert T KinobeKanji Nakatsu
Jul 2, 2011·Parasitology International·Suksanti PrakobwongSomchai Pinlaor
Mar 17, 2006·Journal of Pharmacological and Toxicological Methods·Ryan A DerchoHendrik J Vreman
Aug 3, 2018·Respiratory Research·Kentaro NakashimaTakeshi Kaneko
Aug 8, 2014·Memórias do Instituto Oswaldo Cruz·André M SiqueiraMarcus V G Lacerda

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