Potential insulinominetic agents of zinc(II) complexes with picolinamide derivatives: preparations of complexes, in vitro and in vivo studies

Chemical & Pharmaceutical Bulletin
Eriko UedaYoshitane Kojima

Abstract

Following the finding of in vitro insulinominetic activities of new prepared Zn(II) complexes with amide ligands (2-picolinamide (pa-a) and 6-methyl-2-picolinmethylamide (6mpa-ma)) in isolated rat adipocytes treated with epinephrine in terms of inhibition of free fatty acid release, their blood glucose normalizing effects were observed on daily intraperitoneal injections for 14 d in a type 2 diabetes mellitus model animal, KK-Ay mice. The blood glucose levels of KK-Ay mice were maintained in a normal range during the administration of both complexes. After the administration of each complex for 14 d, the improvement of glucose metabolism was confirmed as judged by the glucose tolerance test.

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Citations

Feb 11, 2003·Chemical & Pharmaceutical Bulletin·Yutaka YoshikawaYoshitane Kojima
Apr 2, 2005·Chemical & Pharmaceutical Bulletin·Eriko UedaNaemi M Kajiwara
Sep 21, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yusuke AdachiHiromu Sakurai
Jun 1, 2007·Expert Opinion on Drug Discovery·Hiromu Sakurai
Mar 3, 2004·Experimental Animals·Masaya KawaseKiyohito Yagi
May 16, 2009·The Journal of Nutritional Biochemistry·Judith JansenLothar Rink
Dec 2, 2006·Life Sciences·Yutaka YoshikawaHiromu Sakurai
Sep 19, 2015·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Priyanga RanasingheGodwin R Constantine
Jun 1, 2005·Journal of Inorganic Biochemistry·Yutaka YoshikawaYoshitane Kojima
Mar 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chika Ifeanyi ChukwumaLimpho M Ramorobi

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