PMID: 6967216May 1, 1980Paper

Potential leukemic cells among bone marrow cells of young AKR/J mice

Proceedings of the National Academy of Sciences of the United States of America
N Haran-Ghera

Abstract

Potentially leukemic cells have been identified among bone marrow cells of AKR/J mice from the age of 14 days onward. Transfer of AKR/J bone marrow into irradiated hybrid mice (AKR/J X DBA/2)F1 caused a high leukemia incidence (50-100%) of AKR origin, very often within a short latent period. Similar transfer of AKR/J marrow into irradiated AKR/J recipients did not enhance spontaneous tumor development. In contrast to the leukemic AKR cells that express the T-cell surface component Thy-1.1, the potential leukemic cells among bone marrow cells of young AKR mice were shown to lack the expression of this antigen. The development of preleukemic AKR marrow into overt leukemia in hybrid mice was dependent on the presence of an intact thymus and exposure of the recipients to x-rays shortly before marrow transfer. Evidently, preleukemic AKR bone marrow undergoes sequential changes, affected by host factors, leading ultimately to development of overt leukemia.

References

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Citations

Dec 1, 1995·Leukemia Research·O AvniM Kotler
Jan 1, 1983·Experimental Gerontology·P EbbesenK Liestöl
Oct 24, 2002·Journal of Virological Methods·Patricia A MathieuLilia A Retegui
Jul 2, 2003·Nature Reviews. Cancer·Donald B KohnJoseph C Glorioso
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M HaasO W Jones
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B R DavisH Fan
Sep 1, 1985·The Journal of Experimental Medicine·A Peled, N Haran-Ghera
Feb 6, 2010·Retrovirology·Prabal BanerjeeGerold Feuer
Jan 1, 1985·International Journal of Radiation Oncology, Biology, Physics·J BoniverE H Betz
Jan 1, 1984·Leukemia Research·E F HaysN Margaretten
Mar 15, 1987·International Journal of Cancer. Journal International Du Cancer·L TrakhtenbrotN Haran-Ghera
Jan 1, 1991·Japanese Journal of Cancer Research : Gann·H Shisa, M Suzuki
Jan 1, 1982·Leukemia Research·N Haran-GheraY Weinstein
Jun 1, 1995·Immunology and Cell Biology·E S Ho, H C O'Neill
Jul 15, 1984·International Journal of Cancer. Journal International Du Cancer·A Peled, N Haran-Ghera
Feb 1, 1992·International Journal of Cancer. Journal International Du Cancer·E YefenofE S Vitetta

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