Potential mechanisms by which Peceol increases the gastrointestinal absorption of amphotericin B

Drug Development and Industrial Pharmacy
Verica RisovicK M Wasan

Abstract

The purpose of this study was to ascertain how the incorporation of AmpB into a glyceride-rich excipient Peceol significantly increased Amphotericin B's (AmpB) gastrointestinal absorption in white male Sprague-Dawley rats. Based on preliminary studies, our working hypothesis was that incorporation of AmpB into mixed micelles composed of Peceol would significantly enhance gastro-intestinal (GI) tract absorption by increasing lymphatic drug transport and decreasing P-glycoprotein (PGP)-mediated drug efflux. I. Lymphatic Transport Following an overnight fast (12-16 hr) and 48 hr postsurgery, rats were divided into two treatment groups and received a single-dose oral gavage (1 mL total volume) at 0700 h of either desoxycholate (DOC)-AmpB (5 mg AmpB/kg; n = 6 at each time point) or AmpB incorporated into 100% Peceol (Peceol-AmpB; 5 mg AmpB/kg; n = 6 at each time point). Mesenteric lymph samples were obtained prior to and at 0-4-hr, 4-6-hr, and 6-8-hr intervals post oral gavage. An equal volume of normal saline (1 mL) was administered intravenously to the animal following each blood draw to prevent fluid depletion throughout the duration of the study. Lymph was immediately harvested by centrifugation and analyzed for drug by high-per...Continue Reading

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Citations

Apr 29, 2009·The Journal of Antimicrobial Chemotherapy·Pavel GershkovichKishor M Wasan
Jan 17, 2016·The Journal of Pharmacy and Pharmacology·Amal A SultanGamal M El Maghraby
Jun 10, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Subhashis ChakrabortySanjay Singh
Jan 18, 2008·Advanced Drug Delivery Reviews·Joseph M CustodioLeslie Z Benet
Jun 18, 2017·Journal of Liposome Research·Amal A SultanGamal M El Maghraby
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Cheri A BartaChris Orvig
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Feb 6, 2017·Drug Delivery·Min LiuZhiwen Yang
Mar 8, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wanshan FengPavel Gershkovich

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