Potential mechanisms by which Peceol increases the gastrointestinal absorption of amphotericin B

Drug Development and Industrial Pharmacy
Verica RisovicK M Wasan


The purpose of this study was to ascertain how the incorporation of AmpB into a glyceride-rich excipient Peceol significantly increased Amphotericin B's (AmpB) gastrointestinal absorption in white male Sprague-Dawley rats. Based on preliminary studies, our working hypothesis was that incorporation of AmpB into mixed micelles composed of Peceol would significantly enhance gastro-intestinal (GI) tract absorption by increasing lymphatic drug transport and decreasing P-glycoprotein (PGP)-mediated drug efflux. I. Lymphatic Transport Following an overnight fast (12-16 hr) and 48 hr postsurgery, rats were divided into two treatment groups and received a single-dose oral gavage (1 mL total volume) at 0700 h of either desoxycholate (DOC)-AmpB (5 mg AmpB/kg; n = 6 at each time point) or AmpB incorporated into 100% Peceol (Peceol-AmpB; 5 mg AmpB/kg; n = 6 at each time point). Mesenteric lymph samples were obtained prior to and at 0-4-hr, 4-6-hr, and 6-8-hr intervals post oral gavage. An equal volume of normal saline (1 mL) was administered intravenously to the animal following each blood draw to prevent fluid depletion throughout the duration of the study. Lymph was immediately harvested by centrifugation and analyzed for drug by high-per...Continue Reading


Mar 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R D Meyer
Oct 1, 1988·Pharmaceutical Research·J P ReymondJ Vonderscher
May 1, 1994·Antimicrobial Agents and Chemotherapy·P ChavanetP Yeni
Jun 1, 1993·Journal of Clinical Pharmacy and Therapeutics·C Gates, R J Pinney
Jul 1, 1995·The Journal of Antimicrobial Chemotherapy·M R LanceS S Davis
Sep 1, 1996·Pharmaceutical Research·U FagerholmH Lennernäs
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M KolaczkowskiA Goffeau
Jan 7, 1999·Drug Development and Industrial Pharmacy·J S DangiV K Dixit
Aug 31, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·L C SouzaA Campa
Aug 8, 2001·Advanced Drug Delivery Reviews·C J Porter, W N Charman
Oct 16, 2002·Journal of Pharmaceutical Sciences·E Sócrates T EgitoJames C Price
Nov 29, 2002·Drug Development and Industrial Pharmacy·Kishor M Wasan
Dec 14, 2002·International Journal of Pharmaceutics·Y V Rama PrasadKanji Takada

❮ Previous
Next ❯


Apr 29, 2009·The Journal of Antimicrobial Chemotherapy·Pavel GershkovichKishor M Wasan
Jan 17, 2016·The Journal of Pharmacy and Pharmacology·Amal A SultanGamal M El Maghraby
Jun 10, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Subhashis ChakrabortySanjay Singh
Jan 18, 2008·Advanced Drug Delivery Reviews·Joseph M CustodioLeslie Z Benet
Jun 18, 2017·Journal of Liposome Research·Amal A SultanGamal M El Maghraby
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Cheri A BartaChris Orvig
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Feb 6, 2017·Drug Delivery·Min LiuZhiwen Yang
Mar 8, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wanshan FengPavel Gershkovich

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.