Potential mechanisms of improvement of airway hyperresponsiveness by inhaled corticosteroid therapy in asthmatic patients

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Saeko NomuraJunichi Yoshikawa

Abstract

Recent clinical trials with administration of IL-5 antibodies to asthmatic patients have revealed reduction of eosinophilia but unaltered airway hyperresponsiveness (AHR). In contrast, inhaled corticosteroid (ICS) therapy eliminates both eosinophilia and AHR. This study was designed to examine the mechanisms by which ICS improves airway hyperresponsiveness in asthmatic patients. Clinical variables of asthma involving vascular permeability and IL-5 levels were examined in 23 asthmatic patients and 11 normal control subjects. After the first sputum induction, inhaled beclomethasone dipropionate (BDP 800 microg/day) was administered to asthmatic patients for 8 weeks, and sputum induction was repeated. IL-5 levels in induced sputum and airway vascular permeability index were significantly higher in asthmatic patients. IL-5 was positively correlated with percentage of eosinophils in induced sputum, and negatively correlated with FEV1, but not correlated with PC20 methacholine. After BDP therapy, eosinophils, ECP, and IL-5 levels were significantly decreased to the same levels as in normal subjects. Conversely, PC20 methacholine and airway vascular permeability did not improve to the same levels as in normal subjects. Increase in PC2...Continue Reading

References

May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Feb 1, 1990·The Journal of Allergy and Clinical Immunology·G J Gleich
Jan 1, 1993·European Journal of Clinical Pharmacology·R P Schleimer
Jun 1, 1995·Clinical and Experimental Pharmacology & Physiology·R G Goldie, K E Pedersen
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·H Z ShiZ F Xie
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·M M PizzichiniF E Hargreave
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·A JatakanonP J Barnes
Feb 7, 2001·Chest·M J Alvarez-PueblaA I Tabar-Purroy
Apr 9, 2001·Immunological Reviews·P S FosterD C Webb
Nov 22, 2001·The European Respiratory Journal·M M KellyG Cox
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Elizabeth L J Van RensenPeter J Sterk
Dec 7, 2002·American Journal of Respiratory and Critical Care Medicine·Alfredo ChettaDario Olivieri
Mar 22, 2003·American Journal of Respiratory and Critical Care Medicine·Johan C KipsRomain A Pauwels
Aug 14, 2003·International Archives of Allergy and Immunology·Sung Woo ParkChoon-Sik Park
Mar 27, 2004·American Journal of Respiratory and Critical Care Medicine·Hiroshi KanazawaJunichi Yoshikawa

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Citations

Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hee Sun ParkYong Chul Lee
Apr 23, 2010·Biological & Pharmaceutical Bulletin·Kumiko GotoMiwa Misawa
Jul 1, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Min-Hye KimSang-Heon Cho

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