PMID: 9436152Jan 22, 1998Paper

Potential mechanisms of moxonidine-induced ocular hypotension: role of norepinephrine

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
T C ChuD E Potter

Abstract

In rabbit's aqueous humor, norepinephrine, epinephrine, dopamine and serotonin were detected simultaneously by a high performance liquid chromatography with electrochemical detection. Furthermore, the changes in catecholamine levels in aqueous humor were evaluated after topical application of moxonidine, an imidazoline1/alpha 2 receptor agonist, in the presence and absence of efaroxan. The level of norepinephrine in aqueous humor was reduced by moxonidine treatment. However, under the same set of conditions, there were no significant changes in the levels of dopamine, epinephrine or serotonin. Pretreatment with efaroxan antagonized moxonidine-induced suppression of norepinephrine levels. In other in vivo experiments, moxonidine caused a decrease in intraocular pressure which was antagonized by pretreatment with efaroxan. In the superior cervical ganglion preparation, norepinephrine release was increased 5-fold by the presence of a high K+ medium. The K(+)-evoked norepinephrine secretion was reduced by 55% by moxonidine. Pretreatment with efaroxan blocked the moxonidine-induced inhibition of norepinephrine release. It is concluded that inhibition of norepinephrine release from the superior cervical ganglion and suppression of aq...Continue Reading

References

Nov 21, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·J P NoonR H Roth
Sep 1, 1992·Current Eye Research·Y Kiuchi, D S Gregory
Jun 1, 1984·Current Eye Research·R L CooperL Davidson

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Citations

Aug 19, 1999·Brain Research Bulletin·C Farsang, J Kapocsi
Sep 12, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Teh-Ching Chu, David E Potter
Apr 1, 2000·Clinical and Experimental Hypertension : CHE·R R SocciM A Bayorh
Jan 6, 2000·Experimental Eye Research·E ChuD E Potter
May 31, 2011·Biochemical and Biophysical Research Communications·Young-Hwan KimSeungsoo Chung
Mar 12, 2002·Bioorganic & Medicinal Chemistry·Christophe DardonvilleJ Javier Meana
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Walter RaaschPeter Dominiak

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