Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer

Non-coding RNA
Jun Sheng Wong, Yoke Kqueen Cheah

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications.

References

Aug 5, 2006·Breast Cancer Research : BCR·Anna Fantozzi, Gerhard Christofori
Sep 20, 2006·Cancer Research·Yuki TsuchiyaTsuyoshi Yokoi
Jan 11, 2008·Nature·Sohail F TavazoieJoan Massagué
Jan 15, 2008·Nature Cell Biology·Qihong HuangReuven Agami
Jan 24, 2008·Molecular and Cellular Biology·Irena IvanovskaMichele A Cleary
Aug 13, 2008·The Journal of Cell Biology·Zuoren YuRichard G Pestell
Oct 17, 2008·Cancer Research·Sirigiri Divijendra Natha ReddyRakesh Kumar
Dec 17, 2008·The Journal of Biological Chemistry·Rebecca J WebsterPeter J Leedman
Feb 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mohit SachdevaYin-Yuan Mo
Apr 4, 2009·The Journal of Biological Chemistry·Ashley J Pratt, Ian J MacRae
Jul 4, 2009·The Journal of Biological Chemistry·Irene K Guttilla, Bruce A White
Oct 31, 2009·RNA Biology·Xu GuoRebecca S Hartley
Dec 10, 2009·Cancer Research·Mohit Sachdeva, Yin-Yuan Mo
Feb 23, 2010·Nature Cell Biology·Li MaRobert A Weinberg
Mar 30, 2010·Journal of Experimental & Clinical Cancer Research : CR·Bao SongXianrang Song
Apr 8, 2010·The Journal of Biological Chemistry·William KongJin Q Cheng
Jul 7, 2010·Cell·Graziano MartelloStefano Piccolo
Sep 4, 2010·Breast Cancer Research : BCR·Aleix PratCharles M Perou
Sep 23, 2010·BMC Cancer·Aoife J LoweryMichael J Kerin
Nov 26, 2010·International Journal of Cancer. Journal International Du Cancer·Khalid Sossey-AlaouiEdward F Plow
Dec 15, 2010·Molecular Oncology·Aleix Prat, Charles M Perou
Feb 10, 2011·The Oncologist·Clifford A Hudis, Luca Gianni
Apr 12, 2011·Molecular Carcinogenesis·Vipin Yadav, Mitchell F Denning
Jul 27, 2011·Biochemical and Biophysical Research Communications·Ryohei AdachiToshiyuki Sakamaki
Sep 29, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yinghua ZhuErwei Song
Oct 11, 2011·Molecular Cell·Joerg E BraunElisa Izaurralde
Nov 2, 2011·The Breast : Official Journal of the European Society of Mastology·Marilena V IorioElda Tagliabue
Oct 26, 2011·The Journal of Cell Biology·Nam Hee KimJong In Yook
Nov 25, 2011·Breast Cancer Research : BCR·Yee-Ming LeeHuei-Wen Chen
May 15, 2012·Molecular Oncology·Claudia PiovanCarlo M Croce

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Citations

Mar 28, 2021·International Ophthalmology·Xiu-Hong LiHong-Feng Yuan

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Methods Mentioned

BETA
xenograft
xenografts
flow cytometry
transfecting
transfection
gene knockdown
gene-knockout

Software Mentioned

GLOBOCAN

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