Potential misinterpretation of infant lung function unless prospective healthy controls are studied

Pediatric Pulmonology
Sooky LumJanet Stocks

Abstract

SUMMARY RATIONALE: Reliable interpretation of pulmonary function tests relies on appropriate reference data, which remain very limited for infants. This study aimed to assess the validity of published reference equations for forced expiratory flow-volume (FEFV) data in infants when using current, commercially available equipment, and how this could impact on interpretation of results from infants with lung disease. The Jaeger Masterscreen BabyBody (v4.67) equipment was used to perform partial and raised volume FEFV maneuvers in healthy infants and those with cystic fibrosis (CF). Results were initially expressed as Z-scores using published reference equations. Multilevel modeling was used to calculate differences, if any, from predicted scores in healthy infants. Data were available from 66 healthy full term infants on 89 test occasions; [median (range) postnatal age 49.4 (12-101) weeks. All FEFV outcomes were significantly lower than predicted, with mean (SD) Z-score differences of -0.4 (1.1) for FVC; -0.6 (1.0) for FEV(0.5); -1.0 (1.0) for FEF(25-75) and -1.4 (1.1) for V'(maxFRC). After adjustments using multilevel modeling, mean Z-scores were within 0.1 (SD approximately 1.0) predicted for all outcomes in healthy infants. Am...Continue Reading

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Citations

Oct 3, 2012·Current Opinion in Pulmonary Medicine·Janet StocksSamatha Sonnappa
Dec 3, 2010·American Journal of Respiratory and Critical Care Medicine·Janet StocksRobert Tepper
Sep 28, 2013·Thorax·The Thanh-Diem NguyenUNKNOWN London Cystic Fibrosis Collaboration (LCFC)
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Sep 6, 2012·Pediatric Pulmonology·The Thanh Diem NguyenJanet Stocks
Oct 15, 2013·Pediatric Pulmonology·Ah-Fong HooJanet Stocks
Jul 3, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Diane GrayHeather J Zar
Sep 12, 2015·Pediatric Pulmonology·Hendrik Stefan FischerGerd Schmalisch
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