Potential Nutraceutical Properties of Leaves from Several Commonly Cultivated Plants.

Biomolecules
Hafsa Amat-Ur-RasoolWayne G Carter

Abstract

Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug reactions, and alternative sources of cholinesterase inhibitors (ChEIs) are required. Herein, we screened methanolic extracts from seven commonly cultivated plants for their nutraceutical potential; ability to inhibit acetylcholinesterase (AChE) and butyryl-cholinesterase (BuChE), and provision of antioxidant activity through their 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging capabilities. Potential neurotoxicity of plant extracts was examined via application to SHSY-5Y neuroblastoma cells and quantitation of cell viability. Methanolic extracts of Citrus limon (Lemon), Bombax ceiba (Red silk-cotton), Lawsonia inermis (Henna), Eucalyptus globulus (Eucalyptus), Ocimum basilicum (Basil), Citrus reticulata (Mandarin orange), and Mentha spicata (Spearmint) all displayed concentration-dependent inhibition of AChE and BuChE. The majority of extracts inhibited AChE and BuChE to near equipotency, with Henna and Eucalyptus extracts the two most potent ChEIs. All plant extracts were able to scavenge free radicals in a con...Continue Reading

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Citations

Feb 6, 2021·Brain Sciences·Hafsa Amat-Ur-RasoolWayne G Carter
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Majid TafrihiRaffaele Pezzani
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Majid Balaei-KahnamoeiMahnaz Khanavi
Aug 28, 2021·Biomolecules·Jan Korabecny, Ondrej Soukup

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Software Mentioned

GraphPad Prism
MassLynx
AutoDock Vina
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PyMOL

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