Potential of algal metabolites for the development of broad-spectrum antiviral therapeutics: Possible implications in COVID-19 therapy

Phytotherapy Research : PTR
Rimjhim SangtaniKiran Bala

Abstract

Covid-19 pandemic severely affected human health worldwide. Till October 19, 2020, total confirmed patients of COVID-19 are 39,944,882, whereas 1,111,998 people died across the globe. Till to date, we do not have any specific medicine and/or vaccine to treat COVID-19; however, research is still going on at war footing. So far vaccine development is concerned, here it is noteworthy that till now three major variants (named A, B, and C) of severe acute respiratory syndrome-coronavirus2 (SARS-CoV-2) have been recognized. Increased mutational rate and formation of new viral variants may increase the attrition rate of vaccines and/or candidate chemotherapies. Herbal remedies are chemical cocktails, thus open another avenue for effective antiviral therapeutics development. In fact, India is a large country, which is densely populated, but the overall severity of COVID-19 per million populations is lesser than any other country of the world. One of the major reasons for the aforesaid difference is the use of herbal remedies by the Government of India as a preventive measure for COVID-19. Therefore, the present review focuses on the epidemiology and molecular pathogenesis of COVID-19 and explores algal metabolites for their antiviral p...Continue Reading

References

Jul 1, 1978·Antimicrobial Agents and Chemotherapy·J T RichardsM T Hatch
Aug 16, 1989·Journal of the National Cancer Institute·K R GustafsonM R Boyd
May 1, 1994·Preparative Biochemistry·V IvanovaN Manolova
Nov 14, 1997·General Pharmacology·M Witvrouw, E De Clercq
May 21, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S AyehunieR M Ruprecht
Aug 14, 1998·Biological & Pharmaceutical Bulletin·T HoshinoU Sankawa
Dec 1, 2000·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·J Serkedjieva
Apr 20, 2001·Chemical & Pharmaceutical Bulletin·S PreeprameT Hayashi
Mar 5, 2003·Biochemistry·Heidi R BokeschMichael R Boyd
Apr 10, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Wen ZhuPut O Ang
Apr 30, 2003·Antiviral Research·Laura G BarrientosMichael R Boyd
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Barry R O'KeefeMichael R Boyd
Aug 2, 2003·The New England Journal of Medicine·Gang LiAnlong Xu
Dec 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·P GERBERJ H SHERMAN
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Graham SimmonsPaul Bates
Apr 2, 2004·Biological & Pharmaceutical Bulletin·Mi-Jeong AhnJinwoong Kim
Dec 4, 2004·Nature Medicine·J S M PeirisK Y Yuen
Jul 26, 2005·Journal of Natural Products·Kenji KanekiyoToshimitsu Hayashi
Dec 2, 2005·Planta medica·Helena de Souza PereiraIzabel Christina Frugulhetti
May 2, 2006·Peptides·Changyun XiongJames B McMahon
Jul 1, 2006·The Journal of Biological Chemistry·François HelleJean Dubuisson
Jul 15, 2006·PLoS Pathogens·Christopher B BuckJohn T Schiller
Aug 1, 2006·Advances in Virus Research·Paul S Masters
Aug 4, 2006·Antiviral Research·Sabine RechterManfred Marschall
Oct 4, 2006·Biological & Pharmaceutical Bulletin·Jung-Bum LeeToshimitsu Hayashi
Mar 6, 2007·Virology·Laura B Talarico, Elsa B Damonte
Mar 22, 2007·Virus Research·Mark J CameronDavid J Kelvin
Apr 5, 2007·Nature Protocols·Wouter LaroyNico Callewaert
Apr 25, 2007·Phytochemistry·Kausik ChattopadhyayBimalendu Ray
Apr 27, 2007·Biomacromolecules·Marc Lahaye, Audrey Robic

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Methods Mentioned

BETA
glycosylation
RSA

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