PMID: 15227166Jan 1, 1990Paper

Potential of combined thromboxane A2 and serotonin antagonists to prevent the development of unstable angina and acute myocardial infarction

Texas Heart Institute Journal
James T Willerson, L M Buja

Abstract

We have previously speculated that the abrupt conversion from chronic stable angina to unstable angina and the subsequent progression to acute myocardial infarction may result from myocardial ischemia caused by progressive platelet aggregation and dynamic coronary vasoconstriction. In turn, platelet aggregation and dynamic vasoconstriction probably result from the local accumulation of thromboxane A(2) and serotonin at sites of coronary artery stenosis and endothelial injury; they may also result from relative decreases in the local concentrations of endothelium-derived vasodilators and inhibitors of platelet aggregation, such as endothelium-derived relaxing factors and prostacyclin. Because of severe reductions in coronary blood flow caused by these mechanisms, platelet aggregation may increase, and an occlusive thrombus-composed of platelets, leukocytes, and red blood cells in a fibrin mesh-may develop. When coronary arteries are occluded or narrowed by these mechanisms for a sufficient time, the result may be myocardial necrosis, electrical instability, or sudden death. With respect to the process of coronary artery thrombosis and vasoconstriction, we believe that unstable angina and acute myocardial infarction are 2 element...Continue Reading

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.