Potential of Continuous Manufacturing for Liposomal Drug Products

Biotechnology Journal
Robert D WorshamSuzanne S Farid

Abstract

Over the last several years, continuous manufacturing of pharmaceuticals has evolved from bulk APIs and solid oral dosages into the more complex realm of biologics. The development of continuous downstream processing techniques has allowed biologics manufacturing to realize the benefits (e.g., improved economics, more consistent quality) that come with continuous processing. If relevant processing techniques and principles are selected, the opportunity arises to develop continuous manufacturing designs for additional pharmaceutical products including liposomal drug formulations. Liposome manufacturing has some inherent aspects that make it favorable for a continuous process. Other aspects such as formulation refinement, materials of construction, and aseptic processing need development, but present an achievable challenge. This paper reviews the current state of continuous manufacturing technology applicable to liposomal drug product manufacturing and an assessment of the challenges and potential of this application.

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Citations

May 30, 2019·Psychiatric Services : a Journal of the American Psychiatric Association·Evan A IliakisLois W Choi-Kain
Feb 8, 2019·Biotechnology Journal·Suzanne S Farid
Jul 1, 2020·Advanced Drug Delivery Reviews·Nina FilipczakVladimir P Torchilin
Jan 25, 2021·Journal of Pharmaceutical and Biomedical Analysis·Dorián László GalataZsombor Kristóf Nagy
Nov 12, 2020·Materials·Nikolaos NazirisCostas Demetzos
May 22, 2021·International Journal of Pharmaceutics·Sameera SansareBodhisattwa Chaudhuri

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