Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.

Current Genomics
Mingqing TangRuian Xu

Abstract

Lung cancer, the leading cause of mortality in both men and women in the United States, is largely diagnosed at its advanced stages that there are no effective therapeutic alternatives. Although tobacco smoking is the well established cause of lung cancer, the underlying mechanism for lung tumorigenesis remains poorly understood. An important event in tumor development appears to be the epigenetic alterations, especially the change of DNA methylation patterns, which induce the most tumor suppressor gene silence. In one scenario, DNA methyltransferase (DNMT) that is responsible for DNA methylation accounts for the major epigenetic maintenance and alternation. In another scenario, DNMT itself is regulated by the environment carcinogens (smoke), epigenetic and genetic information. DNMT not only plays a pivotal role in lung tumorigenesis, but also is a promising molecular bio-marker for early lung cancer diagnosis and therapy. Therefore the elucidation of the DNMT and its related epigenetic regulation in lung cancer is of great importance, which may expedite the overcome of lung cancer.

Citations

Jan 12, 2013·Cancer Cell International·Quanyi LuZhipeng Li
Dec 24, 2013·Experimental and Molecular Pathology·Manuraj PandeyKrishna P Gupta
Feb 12, 2013·Translational Oncology·Alice PasiniDaniele Calistri
May 26, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Eric L SceusiCurtis J Wray
Oct 30, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Asok K Dasmahapatra, Ikhlas A Khan
Nov 27, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Loukia G TsaprouniPanos Deloukas
Oct 15, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hong-Tao XuEn-Hua Wang
Sep 12, 2015·Annual Review of Cell and Developmental Biology·Daniel T Swarr, Edward E Morrisey
Jul 18, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Asok K Dasmahapatra, Ikhlas A Khan
May 6, 2015·Cancer Metastasis Reviews·Aditi MehtaGuillermo Barreto
Jun 30, 2018·DNA and Cell Biology·Aladim Gomes LameiraDenise Carleto Andia
Feb 21, 2019·Investigative Ophthalmology & Visual Science·Guangying LuoDongsheng Yan
Nov 17, 2017·Cell Cycle·Mei-Yao HeXuesong Yang
Sep 22, 2015·Current Opinion in Pulmonary Medicine·Katerina M AntoniouCarlo Vancheri
Feb 12, 2020·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Fatemeh ZalMostafa Moradi Sarabi
Jan 1, 2020·Journal of Oncology·Yuan-Xiang ShiXin-Yu Song
Aug 10, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zongmei MouJin Xu
Jan 23, 2014·Development·Michael Herriges, Edward E Morrisey
Aug 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Faye ChleilatRaylene A Reimer

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
xenograft

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.