Potential of FDG-PET as Prognostic Significance after anti-PD-1 Antibody against Patients with Previously Treated Non-Small Cell Lung Cancer

Journal of Clinical Medicine
Kosuke HashimotoIchiei Kuji

Abstract

It remains unclear whether the accumulation of 2-deoxy-2-[18F]fluoro-d-glucose (18F-FDG) before the initiation of anti-programmed death-1 (PD-1) antibody can predict the outcome after its treatment. The aim of this study is to retrospectively examine the prognostic significance of 18F-FDG uptake as a predictive marker of anti-PD-1 antibody. Eighty-five patients with previously treated non-small cell lung cancer (NSCLC) who underwent 18F-FDG-positron emission tomography (PET) just before administration of nivolumab or pembrolizumab monotherapy were eligible in our study, and metabolic tumor volume (MTV), total lesion glycolysis (TLG) and the maximum of standardized under value (SUVmax) on 18F-FDG uptake were assessed. Objective response rate, median progression-free survival and median overall survival were 36.6%, 161 days and 716 days, respectively. The frequency of any immune-related adverse events was significantly higher in patients with low 18F-FDG uptake on PET than in those with high uptake. By multivariate analysis, the tumor metabolic activity by TLG and MTV was identified as an independent prognostic factor for predicting outcome after anti-PD-1 antibody therapy, but not SUVmax, predominantly in patients with adenocarc...Continue Reading

References

Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jul 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kyoichi KairaNobuyuki Yamamoto
Mar 19, 2014·SpringerPlus·Charalampos GkogkouKonstantinos Syrigos
Sep 7, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Hyung-Jun ImDong Soo Lee
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Jul 28, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Laurent DercleSophie Postel-Vinay
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Aug 23, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Kyoichi KairaTakayuki Asao
Oct 14, 2017·Immunological Reviews·Abhishek D Garg, Patrizia Agostinis
Jan 27, 2018·Cell Death & Disease·Marco B SchaafPatrizia Agostinis
Mar 7, 2018·Nature Reviews. Clinical Oncology·Dai FukumuraRakesh K Jain
Aug 5, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kyoichi KairaAkira Mogi
Jun 20, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Mario JreigeNiklaus Schaefer
Jul 20, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Norimitsu KasaharaTakeshi Hisada

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Citations

Jul 30, 2020·Medicina·Maria Isabella DoneganiSilvia Morbelli
Nov 1, 2020·Journal of Clinical Medicine·David LangMichael Gabriel
Jan 15, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Kyoichi KairaHiroshi Kagamu
Feb 3, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Florian EichhornMartin E Eichhorn
Sep 10, 2021·Frontiers in Oncology·David LeungWendy Hayes
Oct 14, 2021·Nature Reviews. Clinical Oncology·Filippo G Dall'OlioBenjamin Besse

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