Potential of Gene and Cell Therapy for Inner Ear Hair Cells

BioMed Research International
Min Yong Lee, Yong-Ho Park

Abstract

Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the "naïve" cochlea. Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss. Cochlear HC regeneration has long been an important goal in the field of hearing research. However, it remains challenging because, thus far, no medical treatment has successfully regenerated cochlear HCs. Recent advances in genetic modulation and developmental techniques have led to novel approaches to generating HCs or protecting against HC loss, to preserve hearing. In this review, we present and review the current status of two different approaches to restoring or protecting hearing, gene therapy, including the newly introduced CRISPR/Cas9 genome editing, and stem cell therapy, and suggest the future direction.

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Citations

Jan 3, 2019·Genomics & Informatics·Nathanial T Carpena, Min Young Lee
Oct 13, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Soumyajit DasRamesh Seepana
Dec 5, 2019·The Journal of the Acoustical Society of America·Gaëlle NaertColleen G Le Prell
Aug 4, 2020·World Journal of Stem Cells·María Beatriz Durán-Alonso
Apr 16, 2019·BioMed Research International·Min Young Lee, Yong-Ho Park
Nov 7, 2018·Journal of Tissue Engineering·Jung-Hwan LeeHae-Won Kim
Sep 10, 2020·Physiological Research·L HeS-S Gong
Nov 3, 2020·Neural Plasticity·Yurong MuDan Li
Jul 3, 2021·International Journal of Molecular Sciences·Yeon Ju KimYun-Hoon Choung

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Methods Mentioned

BETA
cochlear implant
transgenic
genetic modification

Clinical Trials Mentioned

NCT02132130

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