Potential of human induced pluripotent stem cells derived from blood and other postnatal cell types.

Regenerative Medicine
Zhaohui Ye, Linzhao Cheng

Abstract

Human induced pluripotent stem (iPS) cells have been generated from various cell types including blood cells, and offer certain advantages as a starting population for reprogramming postnatal somatic cells. Unlike adult stem cells, iPS cells can proliferate limitlessly in culture while retaining their potential to differentiate into any cell type, including hematopoietic lineages. Derivation of patient-specific iPS cells, in combination with improved hematopoietic differentiation protocols, provides an alternative to generate histocompatible stem cells for bone marrow transplantation. In addition, the ability to reprogram blood cells and redifferentiate iPS cells back to hematopoietic lineages provides opportunities to establish novel models for acquired and inherited blood diseases. This article will summarize recent progress in human iPS cells derived from blood cells and hematopoietic differentiation from iPS cells. Advantages of blood as a source for reprogramming and applications in regenerative medicine will be discussed.

References

Jan 2, 2003·Nature Reviews. Cancer·Alan D D'Andrea, Markus Grompe
Jul 9, 2004·British Journal of Haematology·Marc Tischkowitz, Inderjeet Dokal
Mar 23, 2005·Lancet·E Joanna BaxterUNKNOWN Cancer Genome Project
Apr 29, 2005·The New England Journal of Medicine·Robert KralovicsRadek C Skoda
May 3, 2005·The Journal of Biological Chemistry·Runxiang ZhaoZhizhuang Joe Zhao
Sep 30, 2005·The New England Journal of Medicine·Ayalew TefferiGary Gilliland
Dec 13, 2006·Experimental Hematology·Emmanuel N OlivierEric E Bouhassira
Dec 22, 2006·PloS One·Virginia M ZaleskasRichard A Van Etten
Jun 8, 2007·Nature·Keisuke OkitaShinya Yamanaka
Nov 21, 2007·Hematology·Radek Skoda
Nov 22, 2007·Science·Junying YuJames A Thomson
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·W E LowryK Plath
Feb 26, 2008·Cell·Stuart H Orkin, Leonard I Zon

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Citations

Mar 31, 2012·Science Translational Medicine·Saul J SharkisYoon-Young Jang
Jul 17, 2010·Regenerative Medicine·M William Lensch, Mahendra Rao
Dec 18, 2013·Cellular & Molecular Immunology·Zhengping JiangXuetao Cao
Apr 16, 2020·Stem Cell Reports·Daniel J GarryMary G Garry

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Methods Mentioned

BETA
biopsy
transfection
biopsies
transgenic
gene knockout
xenograft

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