Potential of Lipid Nanoparticles (SLNs and NLCs) in Enhancing Oral Bioavailability of Drugs with Poor Intestinal Permeability

AAPS PharmSciTech
Sushama Talegaonkar, Arundhati Bhattacharyya

Abstract

Lipid-based drug delivery systems has become a popular choice for oral delivery of lipophilic drugs with dissolution rate limited oral absorption. Lipids are known to enhance oral bioavailability of poorly water-soluble drugs in multiple ways like facilitating dissolution as micellar solution, enhancing the lymphatic uptake and acting as inhibitors of efflux transporters. Lipid nanoparticles are matrix type lipid-based carrier systems which can effectively encapsulate both lipophilic and hydrophilic drugs. Lipid nanoparticles namely solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are versatile drug delivery system and can be used for multiple routes of delivery like parenteral, topical, ocular, transdermal, and oral. Lipid nanoparticles are particularly attractive vehicles for peroral delivery of drugs with oral bioavailability problems as they are composed of lipid excipients which are cheap, easily available, and non-toxic; manufacturing technique is simple and readily scalable for large-scale production; the formulations provide controlled release of active components and have no stability issue. A large number of drugs have been incorporated into lipid nanoparticles with the objective of overcoming t...Continue Reading

References

Mar 1, 1991·British Journal of Clinical Pharmacology·J F TjiaD J Back
Sep 1, 1980·The American Journal of Physiology·Y F Shiau, G M Levine
Jan 1, 1995·Pharmaceutical Research·B SjöströmB Cabane
Aug 1, 1993·Canadian Journal of Physiology and Pharmacology·A B ThomsonM T Clandinin
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A SparreboomO van Tellingen
May 11, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Freitas, R H Müller
Jul 25, 2000·Journal of Pharmaceutical Sciences·W N Charman
Aug 30, 2000·Advanced Drug Delivery Reviews·Y H Lee, P J Sinko
Sep 16, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A FundaròM R Gasco
Aug 8, 2001·Advanced Drug Delivery Reviews·C J Porter, W N Charman
Jan 29, 2002·Journal of Microencapsulation·V JenningS H Gohla
Mar 19, 2002·International Journal of Pharmaceutics·M IgartuaJ P Benoit
Aug 15, 2002·International Journal of Pharmaceutics·R H MüllerS A Wissing
Jan 29, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M A Schubert, C C Müller-Goymann
Feb 21, 2003·International Journal of Pharmaceutics·Patrick ShahgaldianMichael J Zaworotko
Apr 25, 2003·International Journal of Pharmaceutics·Michele TrottaOtto Caputo
Aug 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manthena V S VarmaRamesh Panchagnula
Mar 17, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kerstin TabattClaus-Michael Lehr
Apr 15, 2004·Drug Discovery Today·Peter Järver, Ulo Langel
Jun 22, 2005·Cellular and Molecular Life Sciences : CMLS·S DeshayesF Heitz
Apr 4, 2006·International Journal of Pharmaceutics·R H MüllerE B Souto
Mar 3, 2007·Nature Reviews. Drug Discovery·Christopher J H PorterWilliam N Charman
May 10, 2007·Journal of Drug Targeting·Maria Luisa BondiMelchiorre Cervello
Jul 10, 2007·Advanced Drug Delivery Reviews·David J Hauss
Aug 25, 2007·Nanomedicine·Karin Albrecht, Andreas Bernkop-Schnürch
Jul 16, 2008·Expert Opinion on Drug Metabolism & Toxicology·Teruo Murakami, Mikihisa Takano
Jul 31, 2008·Drug Development and Industrial Pharmacy·Marc MuchowRainer H Muller
Jun 30, 2009·Inhalation Toxicology·Matthias NassimiArmin Braun
Nov 10, 2009·Cellular and Molecular Life Sciences : CMLS·F Said HassaneBernard Lebleu
Mar 11, 2010·Handbook of Experimental Pharmacology·Eliana B Souto, Rainer H Müller
Oct 26, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M R Aji AlexE B Souto

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Citations

Feb 1, 2020·Expert Opinion on Therapeutic Patents·Rishi PaliwalMukesh Kumar Sahu
Mar 27, 2020·Pharmaceutics·Mohamed HaiderGorka Orive
Mar 15, 2020·Drug Delivery and Translational Research·Maie S TahaMansoor M Amiji
Aug 18, 2020·International Journal of Nanomedicine·Usama A FahmyNabil A Alhakamy
Sep 5, 2019·Current Pharmaceutical Design·Kuldeep Rajpoot
Aug 28, 2020·Expert Opinion on Drug Delivery·Alejandro Ruiz-PicazoMarta González-Álvarez
Dec 30, 2020·Progress in Lipid Research·David Julian McClements
Nov 17, 2020·Frontiers in Molecular Biosciences·Sebastián Scioli MontotoMaría Esperanza Ruiz
Feb 19, 2021·Biological Trace Element Research·Omid HamidiValiollah Palangi
Jun 25, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Satish RojekarPradeep R Vavia
Aug 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Harsimran Kaur, Prashant Kesharwani
Aug 15, 2021·International Journal of Pharmaceutics·Satish RojekarPradeep Vavia
Nov 13, 2021·ACS Infectious Diseases·Mikel Etxebeste-MitxeltorenaSocorro Espuelas

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Methods Mentioned

BETA
nanoprecipitation
deamination
transfection
flow cytometry

Software Mentioned

SkyePharma
Transcutol

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