PMID: 18434693Apr 25, 2008Paper

Potential of magnetic resonance plaque imaging using superparamagnetic particles of iron oxide for the detection of carotid plaque

Neurologia Medico-chirurgica
Ichiro KawaharaTomayoshi Hayashi

Abstract

Macrophages and by-products are important in plaque destabilization in atherosclerosis. Ultra-small superparamagnetic particles of iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging may be suitable for the detection of macrophages in atherosclerotic plaques. The present study investigated the potential of MR plaque imaging using SPIO in 10 patients scheduled for carotid endarterectomy before and 24-43 hours after administration of SPIO (fercarbotran, 0.016 ml/kg). Three-dimensional gradient recalled acquisition in the steady state (3D-GRASS) was used for detecting macrophages within plaques. Signal loss on the post-contrast 3D-GRASS images was found in 5 of 10 cases, and accumulation of SPIO particles in the vessel wall was confirmed in 4 of these 5 cases. Intracytoplasmic localization of SPIO particles within recruited macrophages was verified by double staining analysis. A correlation between MR plaque imaging using SPIO and localization of macrophages was demonstrated in 6 of 10 patients. This study indicates that MR plaque imaging using SPIO is a potential functional imaging tool to detect infiltration of macrophages in human atherosclerotic carotid plaque.

References

Dec 1, 1977·Circulation Research·E M Renkin
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Oct 15, 1995·Circulation·E Falk, V Fuster
Aug 18, 2001·Circulation Research·Z A Fayad, V Fuster
Oct 13, 2001·Journal of Magnetic Resonance Imaging : JMRI·S A SchmitzB Hamm
May 29, 2003·Journal of Interventional Cardiology·Rob KramsPatrick W Serruys
Feb 8, 2006·Neurosurgery·Masaru HondaTomayoshi Hayashi
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Rikin A TrivediJonathan H Gillard
Jun 23, 2006·Journal of Magnetic Resonance Imaging : JMRI·Christoph U HerbornStefan G Ruehm

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Citations

Mar 24, 2011·Future Medicinal Chemistry·Michael L Matson, Lon J Wilson
Jun 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gerrit L ten KateArend F L Schinkel
Jan 9, 2010·The International Journal of Cardiovascular Imaging·Bernard C M te BoekhorstPieter A F M Doevendans
Sep 12, 2009·Expert Opinion on Drug Delivery·Satish K NuneCory J Berkland
Jun 7, 2011·Neuroimaging Clinics of North America·V E L YoungJ H Gillard
Oct 27, 2010·Current Problems in Cardiology·Gerrit L ten KateArend F L Schinkel
Sep 29, 2011·Journal of Magnetic Resonance Imaging : JMRI·Quan ZhouLin Zhu
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroyuki KatanoSatoru Takahashi
May 24, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Anirban Sen Gupta
Apr 14, 2011·BioTechniques·Anne-Lise AulanierLinda B Andersen
Feb 21, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Tjun Y TangJ H Gillard
Sep 11, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Rohan S WijesurendraRobin P Choudhury
Jul 1, 2009·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Allan W ReidGiles H Roditi
Aug 20, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Timothy J ColganDiego Hernando
Jun 6, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Paolo ArosioClaudio Sangregorio
Jan 4, 2017·Clinical and Translational Medicine·Joyce M S ChanKishore K Bhakoo

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